Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13545
Abstract: Ferroptosis is a regulated form of cell death driven by the lethal accumulation of lipid peroxides in cell membranes. Several regulators of ferroptosis have been identified using cancer cell lines. However, the cellular pathways of… read more here.
Keywords: cell; motor neurons; stem cell; ferroptosis ... See more keywords
Machine learning‐mediated identification of ferroptosis‐related genes in osteonecrosis of the femoral head
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DOI: 10.1002/2211-5463.13764
Abstract: Osteonecrosis of the femoral head (ONFH) is a condition caused by a disruption or damage to the femoral head's blood supply, which causes the death of bone cells and bone marrow components and prevents future… read more here.
Keywords: ferroptosis related; analysis; ferroptosis; femoral head ... See more keywords
Chorein deficiency promotes ferroptosis
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DOI: 10.1002/2211-5463.13870
Abstract: Ferroptosis is a type of programmed cell death owed to an intracellular accumulation of iron resulting in the generation reactive oxygen species, which in turn can cause peroxidation of plasma membrane lipids and ultimately result… read more here.
Keywords: vps13a; chorein deficiency; chorein; ferroptosis ... See more keywords
NR4A1 Exerts Pro-Tumor Role in Glioblastoma via Inducing xCT/GPX4-Regulated Ferroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.70173
Abstract: PURPOSE This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor… read more here.
Keywords: xct; xct gpx4; ferroptosis; tumor ... See more keywords
Fe/Al‐LDH Nanomedicine for Antitumor Ferroptosis‐Immunotherapy by Immunosuppression Reversal
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DOI: 10.1002/adfm.202405483
Abstract: Ferroptosis is recognized as a novel type of programmed cell death with efficient immunogenicity to activate T cell‐mediated adaptive immune responses. However, conventional ferroptosis‐inducers mostly show poor efficacies due to their less effectiveness in immune… read more here.
Keywords: ldh nanomedicine; antitumor ferroptosis; immunotherapy; ferroptosis ... See more keywords
Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy
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DOI: 10.1002/adfm.202419400
Abstract: Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being the inability of chondrocytes to maintain homeostasis in response to the changing stress. The stress response triggered… read more here.
Keywords: mbm; stress; bio heterojunction; ferroptosis ... See more keywords
Self‐Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere‐Aggregated Hydrogels in Triple‐Negative Breast Cancer Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202420430
Abstract: Cisplatin‐loaded hyaluronic acid‐dopamine microsphere (MS) is interconnected by metal ion (e.g., calcium ion and iron ion)‐catechol coordination and polydopamine linkages to form an MS‐aggregated hydrogel (MAH) system to enable convenient peritumoral injection and efficient tumor… read more here.
Keywords: cancer; therapy; mah system; ferroptosis ... See more keywords
GSH‐Responsive Mn2+ Burst Nanoboxes as Mitophagy Intervention Agents Augment Ferroptosis and Chemoimmunotherapy in Triple‐Negative Breast Cancer
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DOI: 10.1002/adfm.202500491
Abstract: Chemoimmunotherapy is recognized as a promising approach for treating cancer patients. However, the overall therapeutic efficacy of treatments for triple‐negative breast cancer (TNBC) is compromised by several factors, including its highly immunosuppressive tumor microenvironment, the… read more here.
Keywords: cancer; breast cancer; negative breast; gsh responsive ... See more keywords
Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
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DOI: 10.1002/adfm.202504775
Abstract: Ferroptosis is a major contributor to intervertebral disc degeneration (IVDD) and represents a promising therapeutic target; however, effective medications that specifically target ferroptosis are still lacking. Consequently, strategies aimed at suppressing the expression of ferroptosis‐related… read more here.
Keywords: disc degeneration; intervertebral disc; sirna delivery; delivery ... See more keywords
Burgeoning Strategies for Cancer Therapy Based on Ferroptosis Induced by Nanomaterials
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DOI: 10.1002/adfm.202511199
Abstract: Ferroptosis, a form of programmed cell death driven by iron‐dependent lipid peroxidation, has emerged as a potent therapeutic avenue against cancer. Recent advances in nanomaterial engineering have enabled precise spatiotemporal control over ferroptosis execution through… read more here.
Keywords: cancer; therapy based; burgeoning strategies; strategies cancer ... See more keywords
Stress Relaxation‐Induced Colon Tumor Multicellular Spheroid Culture Based on Biomimetic Hydrogel for Nanoenzyme Ferroptosis Sensitization Evaluation
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DOI: 10.1002/adhm.202202009
Abstract: Ferroptosis has recently become a research hotspot, and the induction of tumor cell ferroptosis has emerged as a powerful method for tumor therapy. However, the efficiency of tumor cell ferroptosis induction remains unmet for clinical… read more here.
Keywords: cell; multicellular spheroid; tumor; stress relaxation ... See more keywords