Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
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DOI: 10.1002/advs.202310309
Abstract: The recent discovery of copper‐mediated and mitochondrion‐dependent cuproptosis has aroused strong interest in harnessing this novel mechanism of cell death for cancer therapy. Here the design of a core‐shell nanoparticle, CuP/Er, for the co‐delivery of… read more here.
Keywords: cancer; ferroptosis cuproptosis; cuproptosis; synergize ferroptosis ... See more keywords
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
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DOI: 10.1002/smll.202400326
Abstract: The latest research identifies that cysteine (Cys) is one of the key factors in tumor proliferation, metastasis, and recurrence. The direct depletion of intracellular Cys shows a profound antitumor effect. However, using nanozymes to efficiently… read more here.
Keywords: depletion; ferroptosis cuproptosis; tumor; tumor therapy ... See more keywords
Copper-Doped Polydopamine Nanoparticles-Mediated GSH/GPX4-Depleted Ferroptosis and Cuproptosis Sensitizes Lung Tumor to Checkpoint Blockade Immunotherapy.
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DOI: 10.1002/smll.202503208
Abstract: Immune checkpoint blockade (ICB) therapy offers hope for improved outcomes in lung cancer treatment, but its effectiveness is restricted by the presence of an immunosuppressive tumor microenvironment (TME), resulting in a limited response rate (<… read more here.
Keywords: ferroptosis cuproptosis; cuproptosis; checkpoint blockade; lung tumor ... See more keywords
Identification of biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in alcoholic hepatitis by bioinformatics and experimental verification
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1146693
Abstract: Backgrounds Alcoholic hepatitis (AH) is a major health problem worldwide. There is increasing evidence that immune cells, iron metabolism and copper metabolism play important roles in the development of AH. We aimed to explore biomarkers… read more here.
Keywords: cuproptosis; biomarkers associated; associated macrophages; macrophages ferroptosis ... See more keywords
Ferroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances
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DOI: 10.3389/fimmu.2025.1526961
Abstract: Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research and clinical attention. Although ferroptosis and cuproptosis have emerged as significant areas of… read more here.
Keywords: ferroptosis cuproptosis; periodontitis recent; periodontitis; cuproptosis periodontitis ... See more keywords
The Role of Ferroptosis and Cuproptosis in Curcumin against Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041623
Abstract: Background: Among cancer-related deaths, hepatocellular carcinoma (HCC) ranks fourth, and traditional Chinese medicine (TCM) treatment is an important complementary alternative therapy for HCC. Curcumin is a natural ingredient extracted from Curcuma longa with anti-HCC activity,… read more here.
Keywords: hcc; curcumin; analysis; ferroptosis cuproptosis ... See more keywords