Ferroptosis in hepatocellular carcinoma: from bench to bedside.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000390
Abstract: The most widespread type of liver cancer, hepatocellular carcinoma (HCC), is associated with disabled cellular death pathways. Despite therapeutic advancements, resistance to current systemic treatments (including sorafenib) compromises the prognosis of HCC patients, driving the… read more here.
Keywords: hepatocellular carcinoma; hcc; carcinoma bench; ferroptosis hepatocellular ... See more keywords
Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14594
Abstract: Sigma‐1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2‐related factor 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is a strong inducer of ferroptosis but not of apoptosis.… read more here.
Keywords: hepatocellular carcinoma; ferroptosis hepatocellular; hcc cells; ferroptosis ... See more keywords