Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers.
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DOI: 10.1021/acschembio.2c00113
Abstract: Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the molecular basis for this differential ferroptosis sensitivity. We… read more here.
Keywords: erbb3; ferroptosis inducers; nadph nadp; targeting erbb3 ... See more keywords
Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers.
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DOI: 10.1039/d0dt00168f
Abstract: In continuation of the structure-activity study about 4-substituted chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(iii) complexes as necroptosis and ferroptosis inducers, we introduced a 4-COOH group at the 1,2-phenylenediamine moiety of the lead ([Fe(iii)salopheneCl]) and derived the resulting complex 15 to… read more here.
Keywords: iii; iron iii; ferroptosis inducers; necroptosis ferroptosis ... See more keywords
Medroxyprogesterone acetate-resistant endometrial cancer cells are susceptible to ferroptosis inducers.
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DOI: 10.2139/ssrn.4355249
Abstract: AIMS Medroxyprogesterone acetate (MPA) is the most common fertility-sparing treatment in patients with early-stage endometrial cancer. If MPA treatment fails, hysterectomy is recommended. Thus, there is an urgent need for novel treatment approaches for MPA-resistant… read more here.
Keywords: endometrial cancer; mpa resistant; ferroptosis inducers; treatment ... See more keywords
Ferroptosis inducers for prostate cancer therapy.
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DOI: 10.2174/0929867329666220111120924
Abstract: Lipid peroxidation-driven iron-dependent ferroptosis is a regulated cell death mechanism implicated in numerous disease, such as neurological diseases, kidney injury, ischemia, and tumors, including prostate cancer. The cellular mechanisms of ferrosptosis are strongly associated with… read more here.
Keywords: prostate cancer; inducers prostate; ferroptosis inducers; cancer therapy ... See more keywords