Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
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DOI: 10.1136/gutjnl-2022-327909
Abstract: Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in… read more here.
Keywords: ferroptosis induction; combining ferroptosis; blockade; ferroptosis ... See more keywords
Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-0470
Abstract: Abstract Purpose: To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression was measured in SS clinical samples, SS cell… read more here.
Keywords: ferroptosis induction; me1 null; me1 absence; absence ... See more keywords
Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00721
Abstract: Epilepsy is a serious neurological disorder and is characterized by recurrent and unprovoked seizures. A critical pathological factor in the seizure genesis is neuronal loss. Until now, apart from the known regulatory cell death pathways,… read more here.
Keywords: induction pentylenetetrazole; ferroptosis induction; ferroptosis; kindling pilocarpine ... See more keywords