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   Articles with "ferroptosis inflammation" as a keyword



Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-07547-5

Abstract: Preeclampsia (PE) is a pregnancy-specific complication and there remains no effective treatment. Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship… read more here.

Keywords: dysfunction; endothelial dysfunction; ferroptosis inflammation; preeclampsia ... See more keywords

STAT1 promotes ferroptosis and inflammation in mouse hepatic ischemia-reperfusion injury

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08993-x

Abstract: Hepatic ischemia reperfusion injury (HIRI) is a critical complication in liver surgery and transplantation, driven by excessive inflammation and hepatocellular death. Although ferroptosis is recognized as a major form of regulated cell death in HIRI,… read more here.

Keywords: hepatic ischemia; ischemia reperfusion; ferroptosis inflammation; inflammation ... See more keywords

6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/3027514

Abstract: Background Diabetes mellitus (DM) can induce cardiomyocyte injury and lead to diabetic cardiomyopathy (DCM) which presently has no specific treatments and consequently increase risk of mortality. Objective To characterize the therapeutic effect of 6-gingerol (6-G)… read more here.

Keywords: inflammation; nrf2 pathway; ferroptosis inflammation; gingerol ... See more keywords

Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway

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recommendations! Published in 2025 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2025.1526623

Abstract: Introduction Chondrocyte ferroptosis is an important component of the pathogenesis of osteoarthritis. Paeonol, the main pharmacologically active ingredient of the Paeonia suffruticosa Andrews, is a natural radical scavenger with potent biological activities, including antioxidant, anti-inflammatory,… read more here.

Keywords: nrf2 gpx4; inflammation chondrocytes; ampk nrf2; ferroptosis ... See more keywords

Mechanistic and Molecular Insights into Empagliflozin’s Role in Ferroptosis and Inflammation Trajectories in Acetaminophen-Induced Hepatotoxicity

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recommendations! Published in 2025 at "Pharmaceuticals"

DOI: 10.3390/ph18030405

Abstract: Background: Acetaminophen (APAP)-induced acute liver injury (ALI) is increasingly becoming a public health issue with high rate of morbidity and mortality. Therefore, there is a critical demand for finding protective modalities by understanding the underlying… read more here.

Keywords: apap induced; mechanistic molecular; molecular insights; ferroptosis ... See more keywords