Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages.
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DOI: 10.1021/acschembio.2c00869
Abstract: Necrostatin-1 blocks ferroptosis via an unknown mechanism and necroptosis through inhibition of receptor-interacting protein kinase-1 (RIP1). We report that necrostatin-1 suppresses cyclooxygenase-2-dependent prostaglandin biosynthesis in lipopolysaccharide-treated RAW264.7 macrophages (IC50 ∼ 100 μM). This activity is… read more here.
Keywords: prostaglandin synthesis; ferroptosis; activity; ferroptosis inhibitors ... See more keywords
Characterization and role exploration of ferroptosis-related genes in osteoarthritis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1066885
Abstract: Osteoarthritis (OA), viewing as a degenerative aseptic inflammatory disease, is characterized by joint pain and inflammation that significantly affects the quality of patients’ life, especially for the elder. Although rapid progress has been achieved in… read more here.
Keywords: ferroptosis related; characterization role; related genes; ferroptosis ... See more keywords