A Functional Nanocomposite Tri-Activates Cuproptosis, Ferroptosis, and Mitophagy Death Pathway to Oppose Malignancies.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202503530
Abstract: Metal ion dyshomeostasis represents a therapeutic vulnerability in cancer, yet simultaneous targeting of multiple metal-dependent death pathways remains challenging. Herein, a pH-responsive copper-based metal-organic framework nanoplatform (Cu-MOF@DPCPX) is engineered to co-trigger cuproptosis, ferroptosis, and mitophagy… read more here.
Keywords: ferroptosis; ferroptosis mitophagy; tumor; cuproptosis ferroptosis ... See more keywords
Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key Players and PINK1/PARKIN Mediated Mitophagy in an Experimental Parkinson's Rat Model
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70607
Abstract: Parkinson's disease (PD) is the fastest growing neurodegenerative disorder worldwide. Available treatments are only symptomatic, urging the demand for new therapies. Ferroptosis is increasingly reported as a critical player in neurodegeneration. Meanwhile, ferroptosis is activated… read more here.
Keywords: key players; ferroptosis; mitophagy; ferroptosis mitophagy ... See more keywords