ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0305-6
Abstract: It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses without apparent effects on GPX4 function. Instead, ALOX12 inactivation diminishes p53-mediated ferroptosis… read more here.
Keywords: alox12; suppression; ferroptosis pathway; p53 mediated ... See more keywords
Quantification of ferroptosis pathway status revealed heterogeneity in breast cancer patients with distinct immune microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.956999
Abstract: Clinical significance and biological functions of the ferroptosis pathway were addressed in all aspect of cancer regarding multi-omics level; however, the overall status of ferroptosis pathway alteration was hard to evaluate. The aim of this… read more here.
Keywords: breast cancer; ferroptosis pathway; cancer; status ... See more keywords