BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile‐induced mesothelioma via ferroptosis resistance
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DOI: 10.1111/cas.15705
Abstract: Malignant mesothelioma (MM) is still a social burden associated with asbestos exposure. Local iron accumulation thereby represents the major pathogenesis, followed by oxidative DNA strand breaks and genomic alterations in the mesothelium. BRCA1 is a… read more here.
Keywords: brca1; ferroptosis resistance; chrysotile; brca1 mutant ... See more keywords
Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells
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DOI: 10.1155/2022/1608806
Abstract: Objective Cervical cancer (CC) is a prevalent cancer in women. Hypoxia plays a critical role in CC cell ferroptosis resistance. This study explored the mechanism of hypoxia in CC cell ferroptosis resistance by regulating HIF1α/KDM4A/H3K9me3.… read more here.
Keywords: ferroptosis resistance; kdm4a; hif1 transcription; hypoxia ... See more keywords
Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance
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DOI: 10.1155/2022/2985249
Abstract: As a refractory tumor, pancreatic carcinoma is more vulnerable to ferroptosis, a novel regulated cell death mode. However, the exact role of pancreatic stellate cells (PSCs) in pancreatic cancer ferroptosis is still unclear. Using the… read more here.
Keywords: pancreatic cancer; cell; ferroptosis; ferroptosis resistance ... See more keywords
Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney
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DOI: 10.1155/2023/9810733
Abstract: Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of… read more here.
Keywords: ferroptosis resistance; ferroptosis; lupus kidney; cells lupus ... See more keywords
ASS1-mediated reductive carboxylation of cytosolic glutamine confers ferroptosis resistance in cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1999
Abstract: Induction of ferroptosis, a recently defined form of nonapoptotic cell death caused by iron-dependent lipid peroxidation, has emerged as an anti-cancer strategy. Erastin is a ferroptosis activator that promotes cell death that not only depends… read more here.
Keywords: ferroptosis resistance; carboxylation cytosolic; glutamine; cancer ... See more keywords
Abstract 5795: Leukemic stem cells confer ferroptosis resistance in aggressive blood cancer
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DOI: 10.1158/1538-7445.am2023-5795
Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer with limited therapeutic options against leukemic stem cells (LSCs), resulting in poor clinical outcomes for decades. We have demonstrated the clinical importance of aberrant activation of… read more here.
Keywords: ferroptosis resistance; resistance; aggressive blood; blood cancer ... See more keywords
SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance
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DOI: 10.21203/rs.3.rs-1178801/v1
Abstract: Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell sequencing of human… read more here.
Keywords: medullary carcinoma; ferroptosis resistance; renal medullary; ferroptosis ... See more keywords
CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.931749
Abstract: Distant metastasis is the main cause of death in nasopharyngeal carcinoma (NPC) patients. There is an urgent need to reveal the underlying mechanism of NPC metastasis and identify novel therapeutic targets. The ferroptosis resistance and… read more here.
Keywords: metastasis; ferroptosis resistance; caprin2; hmgcr ... See more keywords