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   Articles with "ferroptosis sensitivity" as a keyword



A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.01.043

Abstract: SUMMARY The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using genome-wide human haploid… read more here.

Keywords: sensitivity; ferroptosis; glutathione abundance; ferroptosis sensitivity ... See more keywords
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Prominin-2 Suppresses Ferroptosis Sensitivity.

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recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.11.004

Abstract: Ferroptosis causes clinically relevant amounts of necrosis during the course of heart attacks and acute kidney injury. However, ferroptosis is still a very young research field. In this issue of Developmental Cell, Brown et al. describe… read more here.

Keywords: prominin; ferroptosis; ferroptosis sensitivity; prominin suppresses ... See more keywords

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

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recommendations! Published in 2024 at "Nature Cell Biology"

DOI: 10.1038/s41556-024-01464-1

Abstract: Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal transition (EMT) programme. A mesenchymal phenotype predisposes to ferroptosis, a cell death pathway exerted by… read more here.

Keywords: cancer; cancer cells; zeb1; ferroptosis sensitivity ... See more keywords

Abstract 2820: Intracellular calcium dynamics affect ferroptosis sensitivity

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-2820

Abstract: Melanoma is the deadliest form of skin cancer, and its incidence continues to rise. While advances in immunotherapy, in the form of anti-PD-1, anti-CTLA-4, and anti-LAG-3 immune checkpoint inhibitors, have led to extended cancer-free outcomes… read more here.

Keywords: cancer; melanoma; calcium; ferroptosis sensitivity ... See more keywords

Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity

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recommendations! Published in 2022 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1010436

Abstract: Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA; 20: 3(n-6)) triggers ferroptosis in the germ cells of the… read more here.

Keywords: lipid deficiency; ferroptosis sensitivity; deficiency disrupts; ether lipid ... See more keywords

Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

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recommendations! Published in 2024 at "World Journal of Gastroenterology"

DOI: 10.3748/wjg.v30.i5.485

Abstract: BACKGROUND Gastric cancer (GC) is associated with high mortality rates. Bile acids (BAs) reflux is a well-known risk factor for GC, but the specific mechanism remains unclear. During GC development in both humans and animals,… read more here.

Keywords: cancer; bas; ferroptosis sensitivity; ferroptosis ... See more keywords