A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.043
Abstract: SUMMARY The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using genome-wide human haploid… read more here.
Keywords: sensitivity; ferroptosis; glutathione abundance; ferroptosis sensitivity ... See more keywords
Prominin-2 Suppresses Ferroptosis Sensitivity.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.11.004
Abstract: Ferroptosis causes clinically relevant amounts of necrosis during the course of heart attacks and acute kidney injury. However, ferroptosis is still a very young research field. In this issue of Developmental Cell, Brown et al. describe… read more here.
Keywords: prominin; ferroptosis; ferroptosis sensitivity; prominin suppresses ... See more keywords
Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010436
Abstract: Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA; 20: 3(n-6)) triggers ferroptosis in the germ cells of the… read more here.
Keywords: lipid deficiency; ferroptosis sensitivity; deficiency disrupts; ether lipid ... See more keywords