Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300871
Abstract: Ferroptosis is a form of programmed cell death and plays an important role in many diseases. Dihydroorotate dehydrogenase (DHODH) and glutathione peroxidase 4 (GPX4) play major roles in cell resistance to ferroptosis. Therefore, inactivation of… read more here.
Keywords: ferroptosis therapy; dhodh; protac; gpx4 ... See more keywords
Cyclodextrin-Derived ROS-Generating Nanomedicine with pH-Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy.
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DOI: 10.1002/smll.202200330
Abstract: Nowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti-cancer strategy. Here, the authors utilized pH-sensitive acetalated β-cyclodextrin (Ac-β-CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy… read more here.
Keywords: tumor ferroptosis; cancer; ferroptosis therapy; ferroptosis ... See more keywords
Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy.
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DOI: 10.1002/smll.202202705
Abstract: Because of the insufficiency of hydrogen peroxide, the relatively low rate of Fenton reaction, and the active glutathione (GSH) peroxidase 4 (GPX4) in tumor cells, it is difficult to achieve a desirable efficacy of ferroptosis… read more here.
Keywords: reactive oxygen; ferroptosis therapy; oxygen species; cycloacceleration ... See more keywords
Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System.
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DOI: 10.1021/acsami.2c19585
Abstract: The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis-induced antitumor responses. To solve this issue, we report a strategy to block redox systems… read more here.
Keywords: ferroptosis therapy; redox; synergistic functional; ferroptosis ... See more keywords
Cell-Specific Metabolic Reprogramming of Tumors for Bioactivatable Ferroptosis Therapy.
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DOI: 10.1021/acsnano.1c09480
Abstract: Ferroptosis is a nonapoptotic iron-dependent cell death pathway with a significant clinical potential, but its translation is impeded by lack of tumor-specific ferroptosis regulators and aberrant tumor iron metabolism. Herein, we report a combinational strategy… read more here.
Keywords: tumor; ferroptosis therapy; ferroptosis; tumor cells ... See more keywords
Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy.
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DOI: 10.1021/acsnano.2c02634
Abstract: Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton reaction efficiency, strong intracellular antioxidant system, and insufficient lung drug accumulation limits… read more here.
Keywords: lung; tumor; nanoreactor; ferroptosis therapy ... See more keywords
Synergistic chemo-photothermal and ferroptosis therapy of polydopamine nanoparticles for esophageal cancer.
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DOI: 10.2217/nnm-2022-0064
Abstract: Aim: To develop synergistic chemo-photothermal and ferroptosis therapy nanoparticles to improve the efficacy of treatment for esophageal cancer. Materials & methods: Fe3O4@PDA-HCPT nanoparticles (NPs) were constructed and characterized. Their synergistic antitumor effects were evaluated in EC1… read more here.
Keywords: photothermal ferroptosis; esophageal cancer; ferroptosis therapy; synergistic chemo ... See more keywords