Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300871
Abstract: Ferroptosis is a form of programmed cell death and plays an important role in many diseases. Dihydroorotate dehydrogenase (DHODH) and glutathione peroxidase 4 (GPX4) play major roles in cell resistance to ferroptosis. Therefore, inactivation of… read more here.
Keywords: ferroptosis therapy; dhodh; protac; gpx4 ... See more keywords
Cyclodextrin-Derived ROS-Generating Nanomedicine with pH-Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200330
Abstract: Nowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti-cancer strategy. Here, the authors utilized pH-sensitive acetalated β-cyclodextrin (Ac-β-CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy… read more here.
Keywords: tumor ferroptosis; cancer; ferroptosis therapy; ferroptosis ... See more keywords
Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202202705
Abstract: Because of the insufficiency of hydrogen peroxide, the relatively low rate of Fenton reaction, and the active glutathione (GSH) peroxidase 4 (GPX4) in tumor cells, it is difficult to achieve a desirable efficacy of ferroptosis… read more here.
Keywords: reactive oxygen; ferroptosis therapy; oxygen species; cycloacceleration ... See more keywords
Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19585
Abstract: The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis-induced antitumor responses. To solve this issue, we report a strategy to block redox systems… read more here.
Keywords: ferroptosis therapy; redox; synergistic functional; ferroptosis ... See more keywords
Cell-Specific Metabolic Reprogramming of Tumors for Bioactivatable Ferroptosis Therapy.
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DOI: 10.1021/acsnano.1c09480
Abstract: Ferroptosis is a nonapoptotic iron-dependent cell death pathway with a significant clinical potential, but its translation is impeded by lack of tumor-specific ferroptosis regulators and aberrant tumor iron metabolism. Herein, we report a combinational strategy… read more here.
Keywords: tumor; ferroptosis therapy; ferroptosis; tumor cells ... See more keywords
Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy.
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DOI: 10.1021/acsnano.2c02634
Abstract: Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton reaction efficiency, strong intracellular antioxidant system, and insufficient lung drug accumulation limits… read more here.
Keywords: lung; tumor; nanoreactor; ferroptosis therapy ... See more keywords
Overview and SWOT analysis of nano-ferroptosis therapy for cancers.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale horizons"
DOI: 10.1039/d5nh00170f
Abstract: Cancer remains one of the leading causes of death worldwide. In the search for effective treatments, conventional therapies such as chemotherapy, radiotherapy, and immunotherapy have emerged as mainstream options. However, these therapies often come with… read more here.
Keywords: cancer; ferroptosis therapy; swot analysis; ferroptosis ... See more keywords
Synergistic chemo-photothermal and ferroptosis therapy of polydopamine nanoparticles for esophageal cancer.
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DOI: 10.2217/nnm-2022-0064
Abstract: Aim: To develop synergistic chemo-photothermal and ferroptosis therapy nanoparticles to improve the efficacy of treatment for esophageal cancer. Materials & methods: Fe3O4@PDA-HCPT nanoparticles (NPs) were constructed and characterized. Their synergistic antitumor effects were evaluated in EC1… read more here.
Keywords: photothermal ferroptosis; esophageal cancer; ferroptosis therapy; synergistic chemo ... See more keywords
Recent Advances in Nanotechnology-Based Approaches for Ferroptosis Therapy and Imaging Diagnosis in Pancreatic Cancer
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DOI: 10.3390/pharmaceutics17070937
Abstract: Pancreatic cancer is a highly lethal malignant tumor characterized by challenges in early diagnosis and limited therapeutic options, leading to an exceptionally low clinical cure rate. With the advent of novel cancer treatment paradigms, ferroptosis—a… read more here.
Keywords: pancreatic cancer; ferroptosis; ferroptosis therapy; nanotechnology ... See more keywords