Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Sign Up to like & getrecommendations! Published in 2024 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-024-00454-y
Abstract: Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferroptosis inducers. Ferroptosis is a newly discovered form of programmed cell death caused by iron-dependent lipid peroxidation. In the present study, pacidusin… read more here.
Keywords: ferroptotic cell; ferroptosis; cell; phyllanthus acidus ... See more keywords
Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00561
Abstract: JP4-039 is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow… read more here.
Keywords: cell death; cell; ferroptotic cell; optimization nitroxide ... See more keywords
Iron- and Reactive Oxygen Species-Dependent Ferroptotic Cell Death in Rice-Magnaporthe oryzae Interactions
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell"
DOI: 10.1105/tpc.18.00535
Abstract: Iron- and ROS-dependent accumulation of lipid peroxides is involved in the ferroptotic cell death response in rice during avirulent Magnaporthe oryzae infection. Hypersensitive response (HR) cell death is the most effective plant immune response restricting… read more here.
Keywords: rice; ferroptotic cell; cell death; cell ... See more keywords
Abstract LB267: Disrupting cytoplasmic proton motive force induces ferroptotic cell death in colorectal cancer: A novel anti-cancer mechanism
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb267
Abstract: Introduction: Chemotherapeutic resistance and tumor recurrence remain the leading causes of poor prognosis in colorectal cancer (CRC). Herein, we evaluated the anti-cancer effect of a novel repurposed drug HLN* in CRC. Methods: The changes in… read more here.
Keywords: cancer; ferroptotic cell; anti cancer; cell ... See more keywords
Energy Stress Inhibits Ferroptotic Cell Death via AMPK Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-023
Abstract: In response to glucose starvation, AMPK inhibited lipid peroxidation-associated ferroptosis. read more here.
Keywords: cell death; death via; inhibits ferroptotic; energy stress ... See more keywords
Mitogen-Activated Protein Kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice–Magnaporthe oryzae Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.710794
Abstract: Mitogen-activated protein kinase (MAPK) signaling is required for plant cell death responses to invading microbial pathogens. Iron- and reactive oxygen species (ROS)-dependent ferroptotic cell death occurs in rice (Oryza sativa) during an incompatible rice–Magnaporthe oryzae… read more here.
Keywords: rice; ferroptotic cell; cell death; iron ... See more keywords
Rice iron storage protein ferritin 2 (OsFER2) positively regulates ferroptotic cell death and defense responses against Magnaporthe oryzae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1019669
Abstract: Ferritin is a ubiquitous iron storage protein that regulates iron homeostasis and oxidative stress in plants. Iron plays an important role in ferroptotic cell death response of rice (Oryza sativa) to Magnaporthe oryzae infection. Here,… read more here.
Keywords: cell death; cell; ferroptotic cell; iron ... See more keywords
Mitogen-Activated Protein Kinase Kinase OsMEK2 Positively Regulates Ca2+ Influx and Ferroptotic Cell Death during Rice Immune Responses
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DOI: 10.3390/antiox13081013
Abstract: Mitogen-activated protein (MAP) kinase (MAPK) signaling pathway is important in plant immune responses, involved in iron- and reactive oxygen species (ROS)-dependent ferroptotic cell death mediated by Ca2+. High Ca2+ influx triggered iron-dependent ROS accumulation, lipid… read more here.
Keywords: rice; ferroptotic cell; kinase; cell death ... See more keywords
Jacaric Acid Empowers RSL3-Induced Ferroptotic Cell Death in Two- and Three-Dimensional Breast Cancer Cell Models
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26073375
Abstract: Ferroptosis has recently emerged as a promising strategy to combat therapy-resistant cancers. As lipid peroxidation is a key trigger of ferroptotic cell death, enhancing cancer cell susceptibility through the supply of highly peroxidisable fatty acids… read more here.
Keywords: ferroptotic cell; cancer; breast cancer; cell ... See more keywords
Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023058
Abstract: Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides. The exact mechanism by which… read more here.
Keywords: cell death; cell; ferroptotic cell; pdi ... See more keywords