ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.
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DOI: 10.1093/humrep/dead059
Abstract: STUDY QUESTION Does a homozygous nonsense mutation in ACR lead to total fertilization failure (TFF) resulting in male infertility in humans? SUMMARY ANSWER A novel homozygous nonsense mutation of ACR (c.167G>A, p.Trp56X) was identified in… read more here.
Keywords: acrosin; fertilization; fertilization failure; acrosin deficiency ... See more keywords
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation.
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DOI: 10.1093/humupd/dmad007
Abstract: BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1-3% of ICSI cycles. Oocyte activation deficiency (OAD)… read more here.
Keywords: oocyte activation; fertilization failure; failure; aoa ... See more keywords
Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure
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DOI: 10.1111/cge.14293
Abstract: Total fertilization failure (TFF), which refers to fertilization failure in all mature oocytes, accounting for 5%–10% of in vitro fertilization (IVF) cycles and 1%–3% of intracytoplasmic sperm injection (ICSI) cycles in human. In this study,… read more here.
Keywords: fertilization failure; plcz1 associated; actl7a plcz1; total fertilization ... See more keywords
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect
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DOI: 10.15252/emmm.202216501
Abstract: Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remains to be clarified. In this study, whole‐exome sequencing was firstly used to screen for… read more here.
Keywords: fertilization failure; manchette assembly; male infertility; infertility ... See more keywords
Fertilization failure after human ICSI and the clinical potential of PLCZ1.
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DOI: 10.1530/rep-21-0387
Abstract: Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the sperm oocyte activating factor. At present, there is a general consensus that PLCZ1 is responsible for triggering the calcium (Ca2+) oscillations… read more here.
Keywords: fertilization failure; plcz1; icsi; failure human ... See more keywords
Relationship between sperm quality and total fertilization failure in intracytoplasmic sperm injection and in vitro fertilization cycles: A cross-sectional study
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DOI: 10.18502/ijrm.v20i5.11056
Abstract: Abstract Background Total fertilization failure (TFF) is associated with essential mechanistic and cellular events. Objective The present study is a comprehensive examination of detrimental effects with well-known assays for predicting TFF in conventional in vitro… read more here.
Keywords: quality; fertilization; fertilization failure; vitro fertilization ... See more keywords
Sire contribution to fertilization failure and early embryo survival in cattle.
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DOI: 10.3168/jds.2020-19900
Abstract: Despite passing routine laboratory tests of semen quality, bulls used in artificial insemination (AI) exhibit a significant range in field fertility. The objective of this study was to determine whether subfertility in AI bulls is… read more here.
Keywords: fertilization; fertilization failure; number; embryo ... See more keywords
Predicting the unexpected total fertilization failure in conventional in vitro fertilization cycles: What is the role of semen quality?
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DOI: 10.3389/fcell.2023.1133512
Abstract: Background: Male and female gametes factors might contribute to the total fertilization failure (TFF). In first in vitro fertilization (IVF) cycles, decision-making of insemination protocol was mainly based on semen quality for the contribution of… read more here.
Keywords: semen quality; fertilization; fertilization failure; semen parameters ... See more keywords
Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1086883
Abstract: Fertilization failure during assisted reproductive technologies (ART) is often unpredictable, as this failure is encountered only after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been performed. The etiology of fertilization failure remains… read more here.
Keywords: sperm injection; fertilization; fertilization failure; vitro fertilization ... See more keywords