Comment on “Noninvasive prenatal screening at low fetal fraction: comparing whole‐genome sequencing and single‐nucleotide polymorphism methods”
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DOI: 10.1002/pd.5072
Abstract: This correspondence is in reference to the article entitled, ‘Noninvasive Prenatal Screening at Low Fetal Fraction: Comparing Whole-Genome Sequencing and Single-Nucleotide Polymorphism Methods’ by Artieri, et al., which was recently published in Prenatal Diagnosis. The… read more here.
Keywords: whole genome; low fetal; method; fetal fraction ... See more keywords
Fetal fraction and noninvasive prenatal testing: What clinicians need to know
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DOI: 10.1002/pd.5620
Abstract: The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms used to interpret DNA sequencing results. It is an essential quality control component of noninvasive prenatal testing (NIPT) results. Clinicians need… read more here.
Keywords: clinicians need; prenatal testing; need know; noninvasive prenatal ... See more keywords
The impact of HBB‐related hemoglobinopathies carrier status on fetal fraction in noninvasive prenatal screening
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DOI: 10.1002/pd.6127
Abstract: We evaluated whether there is an association between β‐globin (HBB) pathogenic variants and fetal fraction (FF), and whether the association has a clinically relevant impact on non‐invasive prenatal screening (NIPS). read more here.
Keywords: fetal fraction; prenatal screening; impact hbb;
Association between low fetal fraction in cell-free DNA screening and fetal chromosomal aberrations: A systematic review and meta-analysis.
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DOI: 10.1002/pd.6366
Abstract: OBJECTIVE To perform a systematic review and meta-analysis of the available literature on low fetal fraction (LFF) in cell-free DNA (cfDNA) screening and the risk of fetal chromosomal aberrations. METHOD We searched articles published between… read more here.
Keywords: meta analysis; fetal chromosomal; review; chromosomal aberrations ... See more keywords
Cell-free DNA testing of an extended range of chromosomal anomalies: clinical experience with 6,388 consecutive cases
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DOI: 10.1038/gim.2016.72
Abstract: Purpose:Cell-free DNA (cfDNA) testing for fetal aneuploidies was broadly implemented for common trisomies and sex-chromosome anomalies (SCAs). However, such an approach identifies only 75 to 85% of clinically relevant aneuploidies.Methods:We present a consecutive series of… read more here.
Keywords: dna testing; testing extended; free dna; cell free ... See more keywords
Association of Fetal Fraction of Cell‐Free DNA and Hypertensive Disorders of Pregnancy
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DOI: 10.1055/s-0038-1667374
Abstract: Objective The objective of this study is to examine the relationship between fetal fraction and hypertensive disorders of pregnancy. Study Design This is a retrospective cohort study of women with singleton pregnancies who had cell‐free… read more here.
Keywords: disorders pregnancy; hypertensive disorders; free dna; cell free ... See more keywords
High Fetal Fraction on First Trimester Cell-Free DNA Aneuploidy Screening and Adverse Pregnancy Outcomes.
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DOI: 10.1055/s-0039-1694005
Abstract: OBJECTIVE To test the hypothesis that high fetal fraction (FF) on first trimester cell-free deoxyribonucleic acid (cfDNA) aneuploidy screening is associated with adverse perinatal outcomes. STUDY DESIGN This is a single-institution retrospective cohort study of… read more here.
Keywords: trimester cell; high fetal; cell free; first trimester ... See more keywords
Association between the first and second trimester cell free DNA fetal fraction and spontaneous preterm birth.
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DOI: 10.1080/14737159.2023.2217331
Abstract: OBJECTIVE To evaluate whether the fetal fraction of cell-free DNA at the first and second trimesters is associated with spontaneous preterm birth. METHODS This was a retrospective cohort study with singleton pregnancies who underwent noninvasive… read more here.
Keywords: dna; cell free; fetal fraction; fraction ... See more keywords
A multivariate modeling method for the prediction of low fetal fraction before noninvasive prenatal testing.
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DOI: 10.1177/00368504211052359
Abstract: OBJECTIVE To investigate factors associated with fetal fraction and to develop a new predictive method for low fetal fraction before noninvasive prenatal testing. METHODS The study was a retrospective cohort analysis based on the results… read more here.
Keywords: prenatal testing; low fetal; method; noninvasive prenatal ... See more keywords
Measurement of fetal fraction in cell-free DNA from maternal plasma using a panel of insertion/deletion polymorphisms
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DOI: 10.1371/journal.pone.0186771
Abstract: Objective Cell-free DNA from maternal plasma can be used for non-invasive prenatal testing for aneuploidies and single gene disorders, and also has applications as a biomarker for monitoring high-risk pregnancies, such as those at risk… read more here.
Keywords: panel; fetal fraction; cell free; dna ... See more keywords
The association between fetal fraction and pregnancy-related complications among Chinese population
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DOI: 10.1371/journal.pone.0271219
Abstract: To examine the association of fetal fraction with a wide spectrum of pregnancy-related complications among Chinese population, we carried out a single-institution retrospective cohort study of women with negative Noninvasive prenatal testing (NIPT) results and… read more here.
Keywords: related complications; pregnancy related; association fetal; fetal fraction ... See more keywords