High‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells
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DOI: 10.1111/bjh.16670
Abstract: Sally Killick Aimee Jackson Helen C. Coulthard Christina Yap Emma Das-Gupta Dudley J. Pennell John Porter David Bowen Dominic Culligan Royal Bournemouth and Christchurch NHS Foundation Trust, Cancer Research UK Clinical Trials Unit (CRCTU), University… read more here.
Keywords: haemoglobin pomalidomide; fetal haemoglobin; high level; level induction ... See more keywords
GATA zinc finger domain‐containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β‐thalassaemia through impaired formation of methyl‐binding domain protein 2 (MBD2)‐containing nucleosome remodelling and deacetylation (NuRD) complex
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17511
Abstract: Reactivation of fetal haemoglobin (HbF) expression is an effective way to treat β‐thalassaemia and sickle cell anaemia. In the present study, we identified a novel GATA zinc finger domain‐containing protein 2A (GATAD2A) mutation, which contributed… read more here.
Keywords: protein; fetal haemoglobin; domain containing; gata zinc ... See more keywords
Pharmacologic induction of PGC‐1α stimulates fetal haemoglobin gene expression
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DOI: 10.1111/bjh.18042
Abstract: Sickle cell disease (SCD) is a genetic disorder that affects millions around the world. Enhancement of fetal γ‐globin levels and fetal haemoglobin (HbF) production in SCD patients leads to diminished severity of many clinical features… read more here.
Keywords: fetal haemoglobin; expression; gene expression; globin ... See more keywords
A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia
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DOI: 10.1371/journal.pone.0197927
Abstract: Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia… read more here.
Keywords: fetal haemoglobin; hbs1l myb; cell anaemia; anaemia ... See more keywords