Microbial exposure during early human development primes fetal immune cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.04.039
Abstract: Summary The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of… read more here.
Keywords: exposure; early human; exposure early; fetal immune ... See more keywords
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Research"
DOI: 10.1038/s41390-021-01793-z
Abstract: During the COVID-19 pandemic, thousands of pregnant women have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The implications of maternal SARS-CoV-2 infection on fetal and childhood well-being need to be characterized. We… read more here.
Keywords: maternal sars; absence vertical; fetal immune; sars cov ... See more keywords
Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal‐fetal immune cytopenias
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DOI: 10.1111/trf.16341
Abstract: FcRn, a non‐classical Fc gamma (γ) receptor (FcγR) with near ubiquitous expression, plays key roles in disease pathogenesis and progression though immunoglobulin G (IgG) transport, IgG recycling, and IgG‐immune complex clearance. FcRn function can be… read more here.
Keywords: immune; autoimmune diseases; diseases maternal; fcrn ... See more keywords
In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System
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DOI: 10.3389/fcell.2020.624477
Abstract: Sickle Cell Disease (SCD) is an autosomal recessive disorder resulting from a β-globin gene missense mutation and is among the most prevalent severe monogenic disorders worldwide. Haematopoietic stem cell transplantation remains the only curative option… read more here.
Keywords: disease; immune system; cell disease; fetal immune ... See more keywords
Advances in the study of HLA class Ib in maternal-fetal immune tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.976289
Abstract: The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the… read more here.
Keywords: hla class; immune tolerance; fetal immune; class ... See more keywords