CPHEN‐013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24540
Abstract: Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy and can give rise to all the mature blood cell types in our body, while at the same time maintaining a pool of… read more here.
Keywords: fetal liver; human fetal; hematopoietic stem; stem ... See more keywords
Ex Vivo Modeling of Hematopoietic Stem Cell Homing to the Fetal Liver.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/7651_2020_293
Abstract: Hematopoietic stem cells (HSCs) are used in the clinic to provide life-saving therapies to patients with a variety of hematological malignancies and disorders. Yet, serious deficiencies in our understanding of how HSCs develop and self-renew… read more here.
Keywords: homing fetal; vivo; fetal liver; liver ... See more keywords
Hematopoietic changes in the offspring induced by maternal overweight: Effect on placenta and fetal liver populations.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.02.001
Abstract: INTRODUCTION Bone marrow cells (BMC) from obese adult mice display an increased apoptosis rate over proliferation. Hematopoietic stem cells (HSC) form all blood cells and are important BMC used in cell therapy. Because it is… read more here.
Keywords: fetal liver; maternal overweight; cells hsc; placenta fetal ... See more keywords
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.06.022
Abstract: Summary We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic… read more here.
Keywords: hscs; fetal liver; stem cell; hematopoietic stem ... See more keywords
Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83652-9
Abstract: In order to increase the contribution of donor HSC cells, irradiation and DNA alkylating agents have been commonly used as experimental methods to eliminate HSCs for adult mice. But a technique of HSC deletion for… read more here.
Keywords: hscs; embryos; fetal liver; transplantation ... See more keywords
Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210058120
Abstract: Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs) in the embryo and their development in the fetal liver niche. However, how Notch signaling is activated and which fetal liver cell… read more here.
Keywords: fetal liver; notch signaling; liver; jag1 ... See more keywords
Butyrate ameliorates maternal high-fat diet-induced fetal liver cellular apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270657
Abstract: A maternal high-fat diet (HFD) can impact the offspring’s development of liver steatosis, with fetal development in utero being a crucial period. Therefore, this study investigated the mechanism and whether butyrate can rescue liver injury… read more here.
Keywords: fetal liver; maternal high; liver; hfd ... See more keywords
Therapeutic potential of fetal liver cell transplantation in hemophilia A mice
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282001
Abstract: Hemophilia A (HA) cell therapy approaches in pediatric individuals require suitable factor (F)VIII-producing cells for stable engraftment. Liver sinusoidal endothelial cells (LSEC) and hematopoietic stem cells (HSC) have been demonstrated to be suitable for the… read more here.
Keywords: fetal liver; newborn mice; liver; therapeutic potential ... See more keywords
Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood
Sign Up to like & getrecommendations! Published in 2018 at "PeerJ"
DOI: 10.7717/peerj.5527
Abstract: Background A key event in human development is the establishment of erythropoietic progenitors in the bone marrow, which is accompanied by a fetal-to-adult switch in hemoglobin expression. Understanding of this event could lead to medical… read more here.
Keywords: adult; fetal liver; gene expression; erythroid cells ... See more keywords