Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0475-8
Abstract: Background Therapeutic hypothermia is partially protective for neonatal hypoxic–ischemic encephalopathy (HIE). Damage to the white matter tracts is highly associated with adverse outcomes after HIE, but the effectiveness and optimal duration of hypothermia to attenuate… read more here.
Keywords: term fetal; hypothermia; near term; cerebral hypothermia ... See more keywords
Differentiation potential of neural stem cells derived from fetal sheep
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DOI: 10.1080/19768354.2017.1354915
Abstract: ABSTRACT Neural stem cells (NSCs) are multipotent stem cells that can differentiate into many cell types in vitro. In this study, we isolated and established an NSC line from fetal Ovis aries. Based on the… read more here.
Keywords: potential neural; fetal sheep; differentiation potential; stem ... See more keywords
Primary myoblasts from intrauterine growth-restricted fetal sheep exhibit intrinsic dysfunction of proliferation and differentiation that coincides with enrichment of inflammatory cytokine signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac145
Abstract: Intrauterine growth restriction (IUGR) is linked to lifelong reductions in muscle mass due to intrinsic functional deficits in myoblasts, but the mechanisms underlying these deficits are not known. Our objective was to determine if the… read more here.
Keywords: proliferation; growth; tnf; iugr myoblasts ... See more keywords
Associations between fetal heart rate variability and umbilical cord occlusions‐induced neural injury: An experimental study in a fetal sheep model
Sign Up to like & getrecommendations! Published in 2022 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.14352
Abstract: This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic–ischemic encephalopathy in a fetal sheep model. read more here.
Keywords: fetal heart; sheep model; rate variability; fetal sheep ... See more keywords
Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00472.2018
Abstract: Preterm infants frequently suffer cardiovascular compromise, with hypotension and/or low systemic blood flow, leading to tissue hypoxia-ischemia (HI). Many preterm infants respond inadequately to inotropic treatments using adrenergic agonists such as dobutamine (DB) or dopamine… read more here.
Keywords: hypoxia ischemia; fetal sheep; expression; adrenergic agonists ... See more keywords
The response of fetal sheep cardiomyocytes to intralipid infusion
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735063
Abstract: Introduction: The developing heart undergoes changes in metabolic substrates parallel with perinatal developmental stages. The preferred substrates for fetal hearts are carbohydrates, which transitions to a preference for fatty acids postnatally. The underdevelopment of lipid… read more here.
Keywords: binucleation; intralipid infusion; physiology; fatty acids ... See more keywords
Plasma exosome derived MiR221 as a driver of long term hypoxia induced aberrations in pulmonary arterial phenotype in fetal sheep
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5796248
Abstract: Pregnancy at high altitude (> 2500 meters) reduces oxygenation to the fetus (i.e., gestational hypoxia). The low oxygenation causes abnormal fetal lung development, with pulmonary arteries becoming thicker and dysfunctional. Associated with these structural and… read more here.
Keywords: development; hypoxia; physiology; pulmonary arterial ... See more keywords
The Effect of Antenatal Betamethasone on White Matter Inflammation and Injury in Fetal Sheep and Ventilated Preterm Lambs
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neuroscience"
DOI: 10.1159/000496466
Abstract: Antenatal administration of betamethasone (BM) is a common antecedent of preterm birth, but there is limited information about its impact on the acute evolution of preterm neonatal brain injury. We aimed to compare the effects… read more here.
Keywords: inflammation injury; inflammation; fetal sheep; betamethasone ... See more keywords
Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric and Developmental Pathology"
DOI: 10.1177/1093526619826721
Abstract: Background Perinatal ischemia-reperfusion (I/R) injury of cerebral white matter causes long-term cognitive and motor disabilities in children. I/R damages or kills highly metabolic immature oligodendroglia via oxidative stress, excitotoxicity, inflammation, and mitochondrial dysfunction, impairing their… read more here.
Keywords: matter; fetal sheep; reperfusion; cerebral white ... See more keywords
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02238-4
Abstract: Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administration would attenuate… read more here.
Keywords: term fetal; term; near term; inflammation ... See more keywords
Tissue-specific metabolomic profiling after cardiopulmonary bypass in fetal sheep
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1009165
Abstract: Objective Fetal cardiopulmonary bypass (CPB) is essential to fetal heart surgery, while its development is limited by vital organ dysfunction after CPB. Studying organ metabolism may help to solve this problem. The objective of this… read more here.
Keywords: metabolism; bypass; cpb; tissue specific ... See more keywords