An exploration of the role of Sertoli cells on fetal testis development using cell ablation strategy
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23309
Abstract: Sertoli cells (SCs) are presumed to be the center of testis differentiation because they provide both structural support and biological regulation for spermatogenesis. Previous studies suggest that SCs control germ cell (GC) count and Leydig… read more here.
Keywords: testis; ablation; role; cell ... See more keywords
Dynamics of the transcriptional landscape during human fetal testis and ovary development.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa041
Abstract: STUDY QUESTION Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans? SUMMARY ANSWER The characterization of a dynamically regulated protein-coding and non-coding transcriptional… read more here.
Keywords: human fetal; transcriptional landscape; non coding; expression ... See more keywords
All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy283
Abstract: Humans are universally exposed to low levels of phthalate esters (phthalates), which are used to plasticize polyvinyl chloride. Phthalates exert adverse effects on the development of seminiferous cords in the fetal testis through unknown toxicity… read more here.
Keywords: rat testes; toxicity; fetal rat; retinoic acid ... See more keywords
Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Health Perspectives"
DOI: 10.1289/ehp1014
Abstract: Background: Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied… read more here.
Keywords: endocrine disruption; human fetal; testis explants; disruption human ... See more keywords
Environmental exposures, fetal testis development and function: phthalates and beyond.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-20-0592
Abstract: Fetal development of the mammalian testis relies on a series of interrelated cellular processes: commitment of somatic progenitor cells to Sertoli and Leydig cell fate, migration of endothelial cells and Sertoli cells, differentiation of germ… read more here.
Keywords: fetal testis; testis; testis development; cell ... See more keywords
Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.898876
Abstract: The long-standing knowledge that Sertoli cells determine fetal testosterone production levels is not widespread, despite being first reported over a decade ago in studies of mice. Hence any ongoing use of testosterone as a marker… read more here.
Keywords: cells key; sertoli; key fetal; activin sertoli ... See more keywords
In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01391
Abstract: Atrazine (ATR) is a commonly used agricultural herbicide and a potential endocrine disruptor that may cause testicular dysgenesis. The objective of the present study was to investigate the effects of atrazine on fetal testis development… read more here.
Keywords: utero exposure; testis development; atrazine; fetal testis ... See more keywords