Focus on the frontier issue: progress in noninvasive prenatal screening for fetal trisomy from clinical perspectives
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DOI: 10.1080/10408363.2022.2162843
Abstract: Abstract The discovery of cell-free fetal DNA (cffDNA) in maternal blood and the rapid development of massively parallel sequencing have revolutionized prenatal testing from invasive to noninvasive. Noninvasive prenatal screening (NIPS) based on cffDNA enables… read more here.
Keywords: noninvasive prenatal; prenatal screening; sequencing methods; fetal trisomy ... See more keywords
Effective Fetal Epigenetic Biomarkers for Noninvasive Fetal Trisomy 21 Detections
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DOI: 10.1159/000494054
Abstract: Introduction: Recently, we identified three novel fetal-specific epigenetic DNA regions (FSERs) on chromosome 21 for detection of noninvasive fetal trisomy 21 (T21). In this study, the diagnostic accuracies of the three FSERs were assessed on… read more here.
Keywords: fetal trisomy; pregnant women; noninvasive fetal; t21 ... See more keywords
Outcome after Prenatal Diagnosis of Trisomy 13, 18, and 21 in Fetuses with Congenital Heart Disease
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DOI: 10.3390/life12081223
Abstract: Fetal congenital heart disease (CHD) is often associated with chromosomal abnormalities. Our primary aim was to assess stillbirth and neonatal mortality rates for pregnancies complicated by trisomies 13, 18, and 21 in the presence of… read more here.
Keywords: trisomy; congenital heart; fetal trisomy; prenatal diagnosis ... See more keywords