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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103254
Abstract: The free fatty acid receptor 1 (FFA1) and peroxisome proliferator-activated receptor δ (PPARδ) were considered as potential anti-diabetic targets, and the dual FFA1/PPARδ agonists might provide synergistic effect in insulin secretion and sensibility. Herein, we…
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Keywords:
ppar;
ppar agonists;
ffa1;
potential anti ... See more keywords
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Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2016.1230110
Abstract: Abstract A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these…
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Keywords:
ffa1;
novel ffa1;
ffa1 gpr40;
gpr40 agonists ... See more keywords