Oleic acid promotes prostate cancer malignant phenotype via the G protein‐coupled receptor FFA1/GPR40
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26572
Abstract: Prostate cancer (PCa) is the most commonly diagnosed malignancy in men and the second leading cause of cancer‐related death in industrialized countries. Epidemiologic evidence suggests that obesity promotes aggressive PCa. Recently, a family of Free… read more here.
Keywords: gpr40; pca; ffa1 gpr40; prostate cancer ... See more keywords
Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2016.1230110
Abstract: Abstract A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these… read more here.
Keywords: ffa1; novel ffa1; ffa1 gpr40; gpr40 agonists ... See more keywords