Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120222
Abstract: Stem cell fate is largely determined by cellular signaling networks and is heavily dependent on the supplementation of exogenous recombinant proteins into culture media; however, uneven distribution and inconsistent stability of recombinant proteins are closely… read more here.
Keywords: fgf; controllable optical; fgf signaling; signaling pathway ... See more keywords
GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.11.009
Abstract: Summary Precise control of gene expression during development is orchestrated by transcription factors and co-regulators including chromatin modifiers. How particular chromatin-modifying enzymes affect specific developmental processes is not well defined. Here, we report that GCN5,… read more here.
Keywords: early embryoid; gcn5; fgf signaling; differentiation ... See more keywords
Large-scale analysis of imprinting in naive human pluripotent stem cells reveals recurrent aberrations and a potential link to FGF signaling
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.09.002
Abstract: Summary Genomic imprinting is a parent-of-origin dependent monoallelic expression of genes. Previous studies showed that conversion of primed human pluripotent stem cells (hPSCs) into naive pluripotency is accompanied by genome-wide loss of methylation that includes… read more here.
Keywords: human pluripotent; fgf signaling; pluripotent stem; stem ... See more keywords
The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.12.019
Abstract: Zebrafish have a remarkable ability to regenerate the myocardium after injury by proliferation of pre-existing cardiomyocytes. Fibroblast growth factor (FGF) signaling is known to play a critical role in zebrafish heart regeneration through promotion of… read more here.
Keywords: heart; fgf signaling; injury; heart regeneration ... See more keywords
Corpuscles of Stannius development requires FGF signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.10.005
Abstract: The corpuscles of Stannius (CS) represent a unique endocrine organ of teleostean fish that secrets stanniocalcin-1 (Stc1) to maintain calcium homeostasis. Appearing at 20-25 somite stage in the distal zebrafish pronephros, stc1-expressing cells undergo apical… read more here.
Keywords: stannius development; corpuscles stannius; fgf signaling; requires fgf ... See more keywords
FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0631
Abstract: Cooperativity between WNT and FGF signaling is well documented in embryonic development and cancer progression, but the molecular mechanisms underlying this cross-talk remain elusive. In this study, we interrogated the dynamics of RNA levels, ribosome… read more here.
Keywords: wnt; fgf signaling; translation; pathway components ... See more keywords
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.157874
Abstract: Molecular signaling in the tumor microenvironment (TME) is complex, and crosstalks among various cell compartments in supporting metastasis remain poorly understood. In particular, the role of vascular pericytes, a critical cellular component in the TME,… read more here.
Keywords: macrophage; metastasis; signaling nasopharyngeal; fgf signaling ... See more keywords
FGF Signaling Prevents the Terminal Differentiation of Odontoblasts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Dental Research"
DOI: 10.1177/0022034517691732
Abstract: Members of the fibroblast growth factor (FGF) family play essential and important roles in primary and reparative dentinogenesis, with conflicting results regarding their effects on odontoblast differentiation. Our recent studies showed that the effects of… read more here.
Keywords: pulp; fgf signaling; differentiation; odontoblast differentiation ... See more keywords
FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002050
Abstract: Knowledge of adipogenetic mechanisms is essential to understand and treat conditions affecting organismal metabolism and adipose tissue health. In Drosophila, mature adipose tissue (fat body) exists in larvae and adults. In contrast to the well-known… read more here.
Keywords: fat body; adult adipogenesis; fgf signaling;
FGF Signaling in Lung Development and Disease: Human Versus Mouse
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00170
Abstract: Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs… read more here.
Keywords: fgf signaling; human lung; lung development; mouse ... See more keywords
Structural and Functional Characterization of the FGF Signaling Pathway in Regeneration of the Polychaete Worm Alitta virens (Annelida, Errantia)
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12060788
Abstract: Epimorphic regeneration of lost body segments is a widespread phenomenon across annelids. However, the molecular inducers of the cell sources for this reparative morphogenesis have not been identified. In this study, we focused on the… read more here.
Keywords: fgf; fgf signaling; alitta virens; regeneration ... See more keywords