Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy386
Abstract: Cleidocranial dysplasia (CCD, #119600), which is characterized by hypoplastic clavicles, open fontanelles, supernumerary teeth and a short stature, is caused by heterozygous mutations in RUNX2. However, it currently remains unclear why suture closure is severely… read more here.
Keywords: pthlh signaling; fgf wnt; suture; wnt pthlh ... See more keywords
Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental biology"
DOI: 10.2139/ssrn.4189821
Abstract: In zebrafish, sensory epithelia and neuroblasts of the inner ear form simultaneously in abutting medial and lateral domains, respectively, in the floor of the otic vesicle. Previous studies support regulatory roles for Fgf and Wnt,… read more here.
Keywords: sp5a sp5l; pax2a sp5a; fgf wnt; wnt ... See more keywords