FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22884
Abstract: Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19) gene are found in human breast cancer, mechanisms that contribute to such functional alterations remain elusive. We report here that high expression of… read more here.
Keywords: breast; fgf19; breast cancer; fgfr4 ... See more keywords
FGF19 and FGF21: In NASH we trust
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101152
Abstract: Objective FGF19 and FGF21 have shown therapeutic promise since their discovery, attested by the fact there are at least 5 assets that activate the FGFR/KLB pathway and one FGF19 analog in clinical development. Methods We… read more here.
Keywords: nash trust; fgf21 nash; fgf19 fgf21; fgf19 ... See more keywords
Fibroblast growth factor 19 stimulates water intake
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2022.101483
Abstract: Fibroblast growth factor 19 (FGF19) is a hormone with pleiotropic metabolic functions, leading to ongoing development of analogues for treatment of metabolic disorders. On the other hand, FGF19 is overexpressed in a sub-group of hepatocellular… read more here.
Keywords: growth factor; fibroblast growth; fgf19; water intake ... See more keywords
Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06252-6
Abstract: The gut-derived hormone Fibroblast growth factor 19 (FGF19) could regulate glucose metabolism and is induced by bile acids (BAs) through activating Farnesoid X Receptor (FXR). FGF19 was found to decrease in subjects with isolated-impaired fasting… read more here.
Keywords: cdca; fibroblast growth; impaired fasting; fgf19 ... See more keywords
Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35496-z
Abstract: Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the… read more here.
Keywords: fibrosis; fgf19; non tumorigenic; bile acid ... See more keywords
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD).
Sign Up to like & getrecommendations! Published in 2024 at "Clinical science"
DOI: 10.1042/cs20241137
Abstract: Metabolic dysfunction-associated steatohepatitis (MASH), represents a global health threat. MASH pathophysiology involves hepatic lipid accumulation and progression to severe conditions like cirrhosis and, eventually, hepatocellular carcinoma. Fibroblast growth factor (FGF)-19 has emerged as a key… read more here.
Keywords: fgf19 mrna; dysfunction associated; mash; metabolic dysfunction ... See more keywords
Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13767
Abstract: Human fibroblast growth factor 19 (FGF19, or FGF15 in rodents) plays a central role in controlling bile acid (BA) synthesis through a negative feedback mechanism. This process involves a postprandial crosstalk between the BA‐activated ileal… read more here.
Keywords: fgf19 fgfr4; cholestatic metabolic; fgf19; targeting fgf19 ... See more keywords
FGF19 is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits Lung Fibrosis in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0246oc
Abstract: IPF is a devastating lung disease with limited therapeutic possibilities. FGF19, an endocrine FGF, was recently shown to decrease liver fibrosis. To ask whether FGF19 had anti-fibrotic properties in the lung and decipher its effects… read more here.
Keywords: fgf19 downregulated; downregulated idiopathic; lung fibrosis; fgf19 ... See more keywords
FGF19 is a biomarker associated with prognosis and immunity in colorectal cancer
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320251324401
Abstract: Objective: This study aimed to investigate the relationship between fibroblast growth factor 19 (FGF19) and the prognosis and immune infiltration of colorectal cancer (CRC) and identify the related genes and pathways influencing the onset and… read more here.
Keywords: colorectal cancer; crc; prognosis; fgf19 expression ... See more keywords
Implication of FGFR4 and its ligands in Idiopathic Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa4799
Abstract: IPF is characterized by a reactivation of signaling pathways involved in lung development, such as Fibroblast Growth Factors (FGF). FGFR4 is a FGF receptor activated by endocrine FGFs, such as FGF19, in the presence of… read more here.
Keywords: fibrosis; fgf19; expression; implication fgfr4 ... See more keywords
MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3β/Nrf2/ARE Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s290237
Abstract: Purpose MicroRNAs (miRNAs) are emerging as essential regulators in the development of cerebral ischemia/reperfusion (I/R) injury. This study aimed to explore the regulation of miR-9-3p on FGF19-GSK-3β/Nrf2/ARE signaling in cerebral I/R injury. Materials and Methods… read more here.
Keywords: gsk nrf2; mir; nrf2 signaling; reperfusion ... See more keywords