Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2020.07.013
Abstract: INTRODUCTION AND OBJECTIVES The activation of hepatic stellate cells (HSCs) is the main cause of liver fibrosis. The beneficial effects of fibroblast growth factor (FGF) 19 on liver fibrosis were recently reported. The S. miltiorrhiza… read more here.
Keywords: fgf19 fgfr4; salvianolic acid; fgfr4 signaling; activation ... See more keywords
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma
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DOI: 10.1038/s41598-021-84117-9
Abstract: FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study,… read more here.
Keywords: fgf19 fgfr4; hcc; inhibition; multi kinase ... See more keywords