Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2020.07.013
Abstract: INTRODUCTION AND OBJECTIVES The activation of hepatic stellate cells (HSCs) is the main cause of liver fibrosis. The beneficial effects of fibroblast growth factor (FGF) 19 on liver fibrosis were recently reported. The S. miltiorrhiza… read more here.
Keywords: fgf19 fgfr4; salvianolic acid; fgfr4 signaling; activation ... See more keywords
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84117-9
Abstract: FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study,… read more here.
Keywords: fgf19 fgfr4; hcc; inhibition; multi kinase ... See more keywords
Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases
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DOI: 10.1111/joim.13767
Abstract: Human fibroblast growth factor 19 (FGF19, or FGF15 in rodents) plays a central role in controlling bile acid (BA) synthesis through a negative feedback mechanism. This process involves a postprandial crosstalk between the BA‐activated ileal… read more here.
Keywords: fgf19 fgfr4; cholestatic metabolic; fgf19; targeting fgf19 ... See more keywords
The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Cell International"
DOI: 10.1186/s12935-024-03235-2
Abstract: The FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting the FGF/FGFR pathway, in epithelial ovarian cancer (EOC) and strategies on overcoming AZD4547 resistance.… read more here.
Keywords: cancer; met fgf19; fgf19 fgfr4; drug ... See more keywords
FGF19-FGFR4 axis as the inaugural target for determining the efficacy of advanced esophageal cancer treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.4035
Abstract: 4035 Background: Advanced esophageal cancer (EC) remains a fatal stage with limited survival benefits from current treatments due to lack of specific targets. Esophageal squamous cell carcinoma (ESCC) is the most common type observed in… read more here.
Keywords: cancer; fgf19 fgfr4; anlotinib based; fgf19 amplifications ... See more keywords