Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13582
Abstract: Identifying novel targets that control both tumorigenesis and angiogenesis can aid in developing a more potent anti‐angiogenic therapeutic strategy. We previously reported that reduction of FRG1 is associated with increased p38‐MAPK signaling in prostate cancer… read more here.
Keywords: frg1 expression; erk akt; fgf2; reduced frg1 ... See more keywords
The effect of low molecular weight‐polycyclic aromatic hydrocarbons responsive hsa_circ_0039929/hsa‐miR‐15b‐3p_R‐1/FGF2 circuit on inflammatory response of A549 cells via the PI3K/AKT pathway and epithelial‐mesenchymal transition process
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23546
Abstract: Inflammation is widely recognized as an essential inducer of epithelial‐mesenchymal transition (EMT). Meanwhile, competitive endogenous RNA (ceRNA) has been involved in a variety of disease processes. Therefore, the aim of the current study is to… read more here.
Keywords: circ 0039929; mir 15b; hsa; hsa circ ... See more keywords
Modeling human pancreatic beta cell dedifferentiation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.02.002
Abstract: Objective Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets.… read more here.
Keywords: fgf2; cell dedifferentiation; human pancreatic; expression ... See more keywords
FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101358
Abstract: Objective Fibroblast growth factor 2 (FGF2) has been reported to play divergent roles in white adipogenic differentiation, however, whether it regulates thermogenesis of fat tissues remains largely unknown. We therefore aimed to investigate the effect… read more here.
Keywords: hepatic steatosis; fgf2; adiposity; fat ... See more keywords
Effect of fibroblast growth factor 2 on degenerative endplate chondrocyte: From anabolism to catabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104590
Abstract: BACKGROUND Endplate degeneration is characterized by an unbalance between the anabolism and catabolism of endplate chondrocyte (CH). Fibroblast growth factor 2 (FGF2) has been shown to promote cartilage repair by increasing articular CH anabolic activity.… read more here.
Keywords: catabolism; fgf2; endplate; degeneration ... See more keywords
Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.08.006
Abstract: RATIONALE Among its many biological roles, fibroblast growth factor 2 (FGF2) protects the heart from dysfunction and damage associated with an ischemic attack. Our laboratory demonstrated that its protection against myocardial dysfunction occurs by the… read more here.
Keywords: fgf2; lmw fgf2; hearts expressing; post ischemic ... See more keywords
FGF2 cooperates with IL-17 to promote autoimmune inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07597-8
Abstract: IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic… read more here.
Keywords: cooperates promote; autoimmune inflammation; fgf2; fgf2 cooperates ... See more keywords
The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0871-y
Abstract: FGF2 is a tumor cell survival factor that is exported from cells by an ER/Golgi-independent secretory pathway. This unconventional mechanism of protein secretion is based on direct translocation of FGF2 across the plasma membrane. The… read more here.
Keywords: secretion; atpase; fgf2; interaction ... See more keywords
Structure-guided design, generation, and biofunction of PEGylated fibroblast growth factor 2 variants for wound healing.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr05999d
Abstract: Fibroblast growth factor 2 (FGF2) plays an important role in multiple physiological functions such as tissue repair. However, FGF2 has a short half-life in vivo due to protease degradation, thus limiting its clinical application. Traditional… read more here.
Keywords: wound healing; fgf2; fibroblast growth; structure guided ... See more keywords
CircSLC16A12 Absence Inhibits High Glucose-Induced Dysfunction in Retinal Microvascular Endothelial Cells through Mediating miR-140-3p/FGF2 Axis in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2025845
Abstract: Abstract Purpose Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus which can cause irreversible visual impairment and blindness. We intended to investigate the function of circular RNA (circRNA) solute carrier family 16… read more here.
Keywords: mir 140; absence; diabetic retinopathy; fgf2 ... See more keywords
The FGF2‐induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic‐dependent pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15188
Abstract: In the adult hypothalamus, the neuronal precursor role is attributed to the radial glia‐like cells that line the third‐ventricle (3V) wall called tanycytes. Under nutritional cues, including hypercaloric diets, tanycytes proliferate and differentiate into mature… read more here.
Keywords: tanycyte proliferation; fgf2; induced tanycyte; fgf2 induced ... See more keywords