Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202304304
Abstract: Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation of macrophage in the lung using fibroblast growth factor 21 (FGF21) may be a potential strategy to alleviate… read more here.
Keywords: lung injury; fgf21; efferocytosis; acute lung ... See more keywords
Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202004168
Abstract: Abstract Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21. Whether abnormalities in FGF21… read more here.
Keywords: growth factor; fgf21; factor; fibroblast growth ... See more keywords
Adipose‐derived exosomal MicroRNAs orchestrate gene regulation in the liver: Is this the missing link in nonalcoholic fatty liver disease?
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29343
Abstract: It has long been known that adipose tissue has functions beyond the storage of lipids. More particularly, adipocytes secrete hormones and other molecular cues, including adipokines that actively influence metabolism at distant tissue sites. However,… read more here.
Keywords: mirna; tissue; fgf21; mice ... See more keywords
FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4389-x
Abstract: Aims/hypothesisFibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test… read more here.
Keywords: fgf21; model; glucose homeostasis; body fat ... See more keywords
Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
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DOI: 10.1007/s10753-024-02032-3
Abstract: Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response and energy metabolism. In this study, we engineered… read more here.
Keywords: aging fgf21; fgf21 knockout; investigation; metabolism ... See more keywords
The roles of FGF21 in atherosclerosis pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-019-09488-x
Abstract: FGF21 is a peptide hormone that regulates homeostasis of lipid and glucose as well as energy metabolism. It is mainly expressed and secreted in liver and adipose tissues, and it is expressed in lower amounts… read more here.
Keywords: roles fgf21; fgf21; atherosclerosis pathogenesis; fgf21 atherosclerosis ... See more keywords
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.09.065
Abstract: Summary While the physiological benefits of the fibroblast growth factor 21 (FGF21) hepatokine are documented in response to fasting, little information is available on Fgf21 regulation in a glucose-overload context. We report that peroxisome-proliferator-activated receptor… read more here.
Keywords: ppar; response; glucose response; fgf21 ... See more keywords
FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.022
Abstract: SUMMARY Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor bKlotho (Klb) from the brain produces mice that are… read more here.
Keywords: protein status; fgf21 signals; fgf21; brain ... See more keywords
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
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DOI: 10.1016/j.celrep.2021.109331
Abstract: SUMMARY The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-receptor… read more here.
Keywords: circulating fgf21; gene expression; fgf21; expression ... See more keywords
FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2016.04.027
Abstract: BACKGROUND & AIMS Fibroblast growth factor 19 (FGF19) and 21 (FGF21) have emerged as key regulators of energy homeostasis. Our aim was to analyze the impact of weight loss (WL) induced either by conventional dietary… read more here.
Keywords: serum concentrations; weight loss; fgf19 fgf21; fgf21 ... See more keywords
Circulating fibroblast growth factor 21 as a potential biomarker for missed abortion in humans.
Sign Up to like & getrecommendations! Published in 2021 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2021.05.098
Abstract: OBJECTIVE To investigate whether serum levels of fibroblast growth factor 21 (FGF21) and fatty acid-binding protein-4 (FABP4) are associated with missed abortion (MA) in humans. DESIGN Cross-sectional study. SETTING University-affiliated hospital. PATIENT(S) Patients with MA… read more here.
Keywords: abortion; fibroblast growth; growth factor; fgf21 ... See more keywords