Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
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DOI: 10.1002/jbmr.3761
Abstract: Renal transplantation (RTx) is an effective therapy to improve clinical outcomes in pediatric patients with terminal chronic kidney disease. However, chronic immunosuppression with glucocorticoids (GCs) reduces bone growth and BMD. The mechanisms causing GC‐induced growth… read more here.
Keywords: fgf23; bone growth; bone; expression ... See more keywords
C‐Terminal, but Not Intact, FGF23 and EPO Are Strongly Correlatively Elevated in Patients With Gain‐of‐Function Mutations in HIF2A: Clinical Evidence for EPO Regulating FGF23
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4195
Abstract: Fibroblast growth factor 23 (FGF23) is a key phosphate‐ and vitamin D‐regulating hormone. FGF23 circulates as an intact 251 amino acid protein or N‐ and C‐terminal degradation products. Hormone activity resides in the intact molecule,… read more here.
Keywords: fgf23; function mutations; intact fgf23; physiology ... See more keywords
Biopsychosoziales Betreuungskonzept für Kinder mit X‑chromosomaler Hypophosphatämie (XLH)
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DOI: 10.1007/s00103-020-03171-2
Abstract: Patienten mit einer schweren, seltenen und komplexen Erkrankung benötigen das multiprofessionelle biopsychosoziale Betreuungskonzept eines Sozialpädiatrischen Zentrums für chronisch kranke Kinder und Jugendliche. Am Beispiel der Multiorganerkrankung X‑chromosomale Hypophosphatämie (XLH), der häufigsten angeborenen Rachitisform, wird das… read more here.
Keywords: fgf23; mie xlh; hypophosphat mie; der ... See more keywords
Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats
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DOI: 10.1007/s00223-018-0440-2
Abstract: Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with CKD. However, the mechanisms underlying stimulation of FGF23 remain to be investigated. We examined whether hypercalcemia induced by continuous intravenous (CIV) calcium (Ca)… read more here.
Keywords: fgf23; uremic rats; fibroblast growth; normal uremic ... See more keywords
Tumor-Induced Osteomalacia
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DOI: 10.1007/s00223-020-00691-6
Abstract: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include hypophosphatemia due to renal phosphate wasting, inappropriately normal or frankly low 1,25-dihydroxy-vitamin… read more here.
Keywords: fgf23; tumor induced; tio; induced osteomalacia ... See more keywords
New Therapies for Hypophosphatemia-Related to FGF23 Excess
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DOI: 10.1007/s00223-020-00705-3
Abstract: FGF23 is a hormone produced by osteocytes in response to an elevation in the concentration of extracellular phosphate. Excess production of FGF23 by bone cells, or rarely by tumors, is the hormonal basis for several… read more here.
Keywords: fgf23; fgf23 mediated; treatment; new therapies ... See more keywords
An 8-year-old with genu valgum: Answers
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DOI: 10.1007/s00467-018-4090-4
Abstract: X-ray findings of knee (Fig. 1a, b) and wrist (Fig. 1c) are suggestive of rickets. His laboratory findings showed normal calcium, but low phosphorous, which is suggestive of hypophosphatemic rickets. Differential diagnosis of hypophosphatemic rickets… read more here.
Keywords: fgf23; hypophosphatemic rickets; valgum answers; genu valgum ... See more keywords
Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-021-01250-1
Abstract: Measurement of fibroblast growth factor 23 (FGF23) has been reported to be clinically useful for the differential diagnosis of chronic hypophosphatemia. However, assays for research use only are available in Japan. Thus, the objective of… read more here.
Keywords: fgf23; chemiluminescent enzyme; fgf23 related; hypophosphatemic rickets ... See more keywords
Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats
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DOI: 10.1007/s40618-018-0875-3
Abstract: BackgroundTestosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to… read more here.
Keywords: fgf23; male rats; group; testosterone ... See more keywords
FGF23 and Cardiovascular Risk.
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DOI: 10.1016/j.ando.2020.03.007
Abstract: FGF23 is a protein secreted in the plasma by bone cells. In the kidney, FGF23 can activate an FGF receptor in the presence of its co-receptor αKlotho. FGF23 controls the renal phosphate reabsorption and calcitriol… read more here.
Keywords: fgf23; fgf23 cardiovascular; cardiovascular risk;
Defective O-glycosylation of novel FGF23 mutations in a Chinese family with hyperphosphatemic familial tumoral calcinosis.
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DOI: 10.1016/j.bone.2020.115401
Abstract: OBJECTIVES Hyperphosphatemic familial tumoral calcinosis/hyperostosis-hyperphosphatemia syndrome (HFTC/HHS) is a rare disorder caused by deficiency or resistance of fibroblast growth factor 23 (FGF23). Here we reported a Chinese family with HFTC/HHS, aiming at clarifying the clinical… read more here.
Keywords: fgf23; hyperphosphatemic familial; family; glycosylation ... See more keywords