Targeting FGFR inhibition in cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102170
Abstract: Cholangiocarcinomas (CCAs) are rare but aggressive tumours of the bile ducts, which are often diagnosed at an advanced stage and have poor outcomes on systemic therapy. Somatic alterations with therapeutic implications have been identified in… read more here.
Keywords: targeting fgfr; inhibition; inhibition cholangiocarcinoma; fgfr inhibitors ... See more keywords
Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition
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DOI: 10.1158/1078-0432.ccr-17-1172
Abstract: Purpose: Despite intense research, treatment options for patients with mesothelioma are limited and offer only modest survival advantage. We screened a large panel of compounds in multiple mesothelioma models and correlated sensitivity with a range… read more here.
Keywords: mesothelioma; fgfr inhibition; sensitive fgfr; loss ... See more keywords
Abstract 2929: Radiosensitization of head and neck cancer by FGFR inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2929
Abstract: Objective: Fibroblast growth factor receptors are frequently amplified or overexpressed in head and neck squamous cell carcinomas (HNSCC). We assessed the potential of a selective FGFR-kinase inhibitor, AZD4547, to act as a radiosensitizer in head… read more here.
Keywords: cancer; fgfr inhibition; cell; fgfr ... See more keywords