βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12638
Abstract: Endothelial–mesenchymal transition (EndMT) has emerged as an essential bioprocess responsible for the development of organ fibrosis. We have previously reported that fibroblast growth factor receptor 1 (FGFR1) is involved in the anti‐EndMT effect of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline… read more here.
Keywords: klb; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords
FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split‐Hand/Foot Malformation: Implications for the Promoter Region
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DOI: 10.1002/humu.23178
Abstract: Heterozygous loss‐of‐function mutations of FGFR1 (fibroblast growth factor receptor 1) cause various disorders including hypogonadotropic hypogonadism with split‐hand/foot malformation (HH‐SHFM). We examined FGFR1 in four Japanese patients with HH‐SHFM (cases 1–4) and the mother of… read more here.
Keywords: foot malformation; split hand; fgfr1; hypogonadotropic hypogonadism ... See more keywords
Crosstalk of FGFR1 signaling and choline metabolism promotes cell proliferation and survival in prostate cancer cells
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DOI: 10.1002/ijc.33922
Abstract: The acquisition of ectopic type I fibroblast growth factor receptor (FGFR1) is a common feature of prostate cancer (PCa), the most frequently diagnostic cancer in men. However, how ectopic FGFR1 contributes to PCa progression is… read more here.
Keywords: metabolism; prostate cancer; fgfr1; choline metabolism ... See more keywords
FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice
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DOI: 10.1016/j.celrep.2020.02.052
Abstract: Summary Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of… read more here.
Keywords: sclc; origin sclc; cell origin; fgfr1 ... See more keywords
A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice.
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2018.08.012
Abstract: OBJECTIVE We previously reported that genetic ablation of (Fibroblast Growth Factors Receptors) FGFR1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice, which suggests that FGFR1 is a potential targeting molecule for… read more here.
Keywords: articular cartilage; fgfr1; mice; attenuates degeneration ... See more keywords
Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01280
Abstract: Fibroblast growth factor receptor 1 (FGFR1) is an integral membrane protein that transmits prolife signals through the plasma membrane. Overexpression of FGFR1 has been reported in various tumor types, and therefore, this receptor constitutes an… read more here.
Keywords: 3xgfpp fgf1e; cytotoxic conjugates; oligomeric cytotoxic; intrinsically fluorescent ... See more keywords
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00567-3
Abstract: Fibroblast growth factor receptor (FGFR) is a promising anticancer target. Currently, most FGFR inhibitors lack sufficient selectivity and have nonnegligible activity against kinase insert domain receptor (KDR), limiting their feasibility due to the serious side… read more here.
Keywords: dw14383; fgfr; fgfr inhibitor; fgfr1 ... See more keywords
Maintenance 5-azacytidine therapy by MRD monitoring after allogeneic HSCT in myeloid/lymphoid neoplasms with FGFR1 rearrangement
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DOI: 10.1038/s41409-019-0436-1
Abstract: Myeloid/lymphoid neoplasms with fibroblast growth factor receptor 1 (FGFR1) rearrangement are rare hematological malignancies. In the 2016 World Health Organization classification, they are listed in myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB,… read more here.
Keywords: fgfr1 rearrangement; lymphoid neoplasms; neoplasms fgfr1; fgfr1 ... See more keywords
Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2012073117
Abstract: Significance Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes. Here we show that a bispecific anti-FGFR1/KLB agonist antibody, BFKB8488A, mimics the actions of FGF21 in… read more here.
Keywords: preference; fgfr1; fgfr1 klb; activation fgfr1 ... See more keywords
Pemigatinib for the treatment of myeloid/lymphoid neoplasms with FGFR1 rearrangement
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DOI: 10.1080/14737140.2023.2192930
Abstract: ABSTRACT Introduction Myeloid/lymphoid neoplasms with fibroblast growth factor receptor-1 (FGFR1) rearrangements (MLNFGFR1) are rare entities with aggressive features and poor prognosis. Presentation is heterogeneous, ranging from myeloproliferative neoplasms (with or without eosinophilia) to T-cell lymphoma… read more here.
Keywords: lymphoid neoplasms; fgfr1; pemigatinib; treatment ... See more keywords
Oncogenic FGFR1 mutation and amplification in common cellular origin in a composite tumor with neuroblastoma and pheochromocytoma.
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DOI: 10.1111/cas.15260
Abstract: Neuroblastoma (NB) and pheochromocytoma (PCC) are derived from neural crest cells (NCCs); however, composite tumors with NB and PCC are rare, and their underlying molecular mechanisms remain unknown. To address this issue, we performed exome… read more here.
Keywords: common cellular; oncogenic fgfr1; neuroblastoma pheochromocytoma; cellular origin ... See more keywords