Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG35‐55‐induced EAE through ERK and Akt signalling
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12916
Abstract: Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in demyelinating pathologies including multiple sclerosis (MS). In our recent study, oligodendrocyte‐specific deletion of FGFR1 resulted in a milder disease course, less inflammation, reduced myelin… read more here.
Keywords: oligodendrocyte specific; specific deletion; eae; fgfr2 ... See more keywords
Abstract 2647: Novel FGFR2 biparatopic antibodies for the treatment of cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2647
Abstract: Translocations involving Fibroblast Growth Factor Receptor 2 (FGFR2) are found in up to 45% of Intrahepatic Cholangiocarcinoma (ICC). Treatment of patients bearing FGFR2 fusions with FGFR kinase inhibitors induces tumor regressions, though response rate and… read more here.
Keywords: fusion; fgfr2; growth; biparatopic antibodies ... See more keywords
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000494590
Abstract: Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function of FGFR2… read more here.
Keywords: pi3k akt; fgfr2 tsp4; expression; fgfr2 ... See more keywords
FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-03079-8
Abstract: Background Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet well studied… read more here.
Keywords: poorly cohesive; fgfr2; gene; fgfr2 inhibitors ... See more keywords
Somatic FGFR2 is required for germ cell maintenance in the mouse ovary.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad031
Abstract: During sex determination in the mouse, Fibroblast growth factor 9 (FGF9) signals through the fibroblast growth factor receptor 2c isoform (FGFR2c) to trigger Sertoli cell and testis development from 11.5 days post coitum (dpc). In… read more here.
Keywords: germ cell; fgfr2 required; cell; fgfr2 ... See more keywords
FGFR2 overexpression and compromised survival in diffuse-type gastric cancer in a large central European cohort
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264011
Abstract: The significance of fibroblast growth factor receptor 2 (FGFR2) in gastric cancer (GC) has been studied predominantly in Asian patient cohorts. Data on White patients are scarce. Here, we aimed to independently validate the expression… read more here.
Keywords: fgfr2; expression; gastric cancer; diffuse type ... See more keywords
Circ_0008234 regulates the biological process of gallbladder carcinoma by targeting the miR-204-5p/FGFR2 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-538
Abstract: BACKGROUND Gallbladder carcinoma (GBC) is a common cancer disease with high mortality. Circular RNA_0008234 (circ_0008234) has been shown to play a key role in many tumors, including GBC. However, the function between circ_0008234 and microRNA-204-5p… read more here.
Keywords: fgfr2; gbc; circ 0008234; mir 204 ... See more keywords
Overexpression of fibroblast growth factor receptor 2 in bone marrow mesenchymal stem cells enhances osteogenesis and promotes critical cranial bone defect regeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1208239
Abstract: Background: Reconstruction of cranial bone defects is one of the most challenging problems in reconstructive surgery, and several biological tissue engineering methods have been used to promote bone repair, such as genetic engineering of bone… read more here.
Keywords: regeneration; critical cranial; fgfr2; bone ... See more keywords
Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma
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DOI: 10.3390/cancers12092713
Abstract: Simple Summary FGFR2-ER-PR crosstalk leads to hormone-independent progression of breast cancer. In vitro, FGFR2 stimulates PR transcriptional activity and mediates resistance to anti-ER therapies. The postulated poor prognostic effect of FGFR2 overexpression has not been… read more here.
Keywords: status; breast; hormonal receptor; breast cancer ... See more keywords
FGF2 and FGFR2 in patients with idiopathic pulmonary fibrosis and lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8903
Abstract: The aim of this study was to investigate the expression of FGF2 and FGFR2 in patients with idiopathic pulmonary fibrosis (IPF) and lung cancer (LC) as well as their clinical significance. Reverse transcription-quantitative PCR (RT-qPCR)… read more here.
Keywords: idiopathic pulmonary; expression; cancer; fgfr2 ... See more keywords