Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer
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DOI: 10.1158/1078-0432.ccr-21-1414
Abstract: Purpose: FGFR2 amplification is associated with poor prognosis in advanced gastric cancer and its subclonal heterogeneity has been revealed. Here, we examined whether circulating tumor DNA (ctDNA) was useful for detecting FGFR2 amplification and co-occurring… read more here.
Keywords: ctdna; fgfr2 amplification; cancer; gastric cancer ... See more keywords
Peritoneal Seeding Is More Common in Gastric Cancer Patients with FGFR2 Amplification or High Tumor Mutation Burden
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DOI: 10.3390/diagnostics12102355
Abstract: Fibroblast growth factor receptor-2 (FGFR2) gene alterations have been identified in solid tumors. FGFR2 amplification is found in 2–9% of gastric carcinomas. We hypothesized that FGFR2 could be associated with peritoneal seeding and studied 360… read more here.
Keywords: patients fgfr2; peritoneal seeding; amplification; fgfr2 amplification ... See more keywords