Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor.
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DOI: 10.1021/acsmedchemlett.5c00232
Abstract: Fibroblast growth factor receptors (FGFRs) are well-established oncology targets, with aberrant FGFR2 and FGFR3 activation implicated in multiple tumor types, including cholangiocarcinoma and urothelial carcinoma. Currently approved FGFR2/3-targeted therapies rely on pan-FGFR small-molecule kinase inhibitors,… read more here.
Keywords: potent selective; fgfr2 inhibitor; discovery incb126503; incb126503 potent ... See more keywords
Abstract 1968: Discovery of a highly potent and selective FGFR2 inhibitor for FGFR2-driven cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1968
Abstract: Fibroblast growth factor receptor 2 (FGFR2) is a clinically validated target and frequently altered in many solid tumors. The resulting oncogenic driver alterations often drive multiple solid tumors. Therefore, targeting FGFR2 has broad therapeutic potential.… read more here.
Keywords: potent selective; fgfr2 inhibitor; fgfr2 driven; selective fgfr2 ... See more keywords