FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0399-5
Abstract: Structural rearrangements of the genome can drive lung tumorigenesis through the generation of fusion genes with oncogenic properties. Advanced genomic approaches have identified the presence of a genetic fusion between fibroblast growth factor receptor 3… read more here.
Keywords: fusion; p53; fgfr3 tacc3; lsl f3t3 ... See more keywords
Diffuse gliomas with FGFR3‐TACC3 fusion have characteristic histopathological and molecular features
Sign Up to like & getrecommendations! Published in 2018 at "Brain Pathology"
DOI: 10.1111/bpa.12563
Abstract: Adult glioblastomas, IDH‐wildtype represent a heterogeneous group of diseases. They are resistant to conventional treatment by concomitant radiochemotherapy and carry a dismal prognosis. The discovery of oncogenic gene fusions in these tumors has led to… read more here.
Keywords: fgfr3 tacc3; tacc3 fusion; diffuse gliomas; molecular features ... See more keywords
Varied histomorphology and clinical outcomes of FGFR3-TACC3 fusion gliomas.
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgical focus"
DOI: 10.3171/2022.9.focus22420
Abstract: Targeted therapies for driver gene fusions in cancers have yielded substantial improvements in care. Here, the authors outline a case series of 6 patients with FGFR3-TACC3 fusion in primary brain tumors ranging from polymorphous low-grade… read more here.
Keywords: fusion; varied histomorphology; fgfr3 tacc3; histomorphology clinical ... See more keywords
Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.823015
Abstract: It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH-wild type (GBMs, IDHwt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of “chicken-wire” vessels, microcalcifications and… read more here.
Keywords: fusion; fgfr3 tacc3; morphology; tacc3 ... See more keywords