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   Articles with "fgl1" as a keyword



Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study

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recommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-024-03530-9

Abstract: Hypoxia and tumor cell immunological escape greatly hinder the hepatocellular carcinoma (HCC) treatment efficiency. This study is designed to investigate the capability of carvacrol (CVR) to enhance sorafenib (SOR) anti-cancer efficacy and modulate anti-HCC immunity.… read more here.

Keywords: immunity; hcc; sor; cvr ... See more keywords

Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.767868

Abstract: Fibrinogen-like protein 1 (FGL1) was recently identified as a major ligand of lymphocyte-activation gene-3 (LAG-3) on activated T cells and serves as an immune suppressive molecule for regulation of immune homeostasis. However, whether FGL1 has… read more here.

Keywords: fgl1; induced arthritis; fibrinogen like; collagen induced ... See more keywords

Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.785091

Abstract: LAG3 is the most promising immune checkpoint next to PD-1 and CTLA-4. High LAG3 and FGL1 expression boosts tumor growth by inhibiting the immune microenvironment. This review comprises four sections presenting the structure/expression, interaction, biological… read more here.

Keywords: fgl1; immune checkpoint; lag3; fgl1 cancer ... See more keywords

Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axis

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1014053

Abstract: Rational Lung cancer is the most common tumor worldwide, with the highest mortality rate and second highest incidence. Immunotherapy is one of the most important treatments for lung adenocarcinoma (LUAD); however, it has relatively low… read more here.

Keywords: fgl1; luad; lung; fgl1 myh9 ... See more keywords