The Fgl2 prothrombinase contributes to the pathological process of experimental pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00396.2019
Abstract: In situ thrombus formation is one of the major pathological features of pulmonary hypertension (PH). The mechanism of in situ thrombosis has not been clearly identified. Fgl2 prothrombinase is an immune coagulant that can cleave… read more here.
Keywords: fgl2; fgl2 prothrombinase; situ thrombus; pulmonary hypertension ... See more keywords
Presence and activity of Fibrinogen like protein 2 in platelets
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DOI: 10.1371/journal.pone.0285735
Abstract: Background Fibrinogen-like protein 2 (FGL2) is a serine protease capable of converting prothrombin into thrombin (i.e., prothrombinase-like activity) while bypassing the classic coagulation cascade. It has been reported to be expressed by mononuclear blood cells… read more here.
Keywords: fibrinogen like; activity; like protein; blood ... See more keywords
Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis
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DOI: 10.3390/biom13010089
Abstract: Fibrinogen-like 2 (FGL2) was recently found to be associated with fibrosis in a mouse model of kidney damage and was proposed as a potential therapeutic target in chronic kidney disease (CKD). We assessed the association… read more here.
Keywords: kidney; expression; ckd; analysis ... See more keywords
Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i4.479
Abstract: BACKGROUND Heterogeneous macrophages play an important role in multiple liver diseases, including viral fulminant hepatitis (VFH). Fibrinogen-like protein 2 (FGL2) is expressed on macrophages and regulates VFH pathogenesis; however, the underlying mechanism remains unclear. AIM… read more here.
Keywords: liver damage; fibrinogen like; fulminant hepatitis; fgl2 ... See more keywords
The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.66929
Abstract: Human fibroleukin 2 (Fgl2), a member of the fibrinogen superfamily, can cleave prothrombin to generate thrombin or is secreted in a soluble form as a new type of effector of Tregs with immunomodulatory functions. However,… read more here.
Keywords: tyrobp; cell; cutaneous squamous; cscc ... See more keywords