HIRA loss transforms FH-deficient cells
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DOI: 10.1126/sciadv.abq8297
Abstract: Fumarate Hydratase (FH) is a mitochondrial enzyme that catalyses the reversible hydration of fumarate to malate in the TCA cycle. Germline mutations of FH lead to HLRCC, a cancer syndrome characterised by a highly aggressive… read more here.
Keywords: loss transforms; hira loss; fh1 deficient; deficient cells ... See more keywords