FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13955
Abstract: The four‐and‐a‐half LIM domain protein 1 (FHL1) plays a key role in multiple cancers. Here, we characterized its role in glioblastoma (GBM), the most common and incurable form of brain cancer. Overexpression of FHL1 promotes… read more here.
Keywords: glioblastoma aggressiveness; promotes glioblastoma; egfr expression; fhl1 promotes ... See more keywords
Reducing body myopathy associated with the LIM2 p.(His123Arg) FHL1 variant
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2021.106795
Abstract: Reducing body myopathy (RBM) is a rare muscle disorder, with marked presence of characteristic intracytoplasmic aggregates in affected muscle fibers. RBM is associated with FHL1 gene mutations. Clinical presentations of RBM have ranged from early… read more here.
Keywords: myopathy associated; muscle; body myopathy; fhl1 ... See more keywords
MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/7891222
Abstract: Objective FHL1 is understood as a tumor repressor gene in various cancers and a possible target for cancer treatment. We investigated the influences of FHL1 on cell functions as well as its molecular mechanisms in… read more here.
Keywords: lung adenocarcinoma; fhl1; colony formation; mir ... See more keywords
Aberrant Protein Turn-Over Associated With Myofibrillar Disorganization in FHL1 Knockout Mice
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00273
Abstract: Mutations in the FHL1 gene, and FHL1 protein deletion, are associated with rare hereditary myopathies and cardiomyopathies. FHL1-null mice develop age-dependent myopathy and increased autophagic activity. However, the molecular pathway involved in contractile function and… read more here.
Keywords: protein; myofibrillar disorganization; fhl1 mice; mice ... See more keywords