TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-023-10177-y
Abstract: Differentiation of lens fiber cells involves a complex interplay of signals from growth factors together with tightly regulated gene expression via transcriptional and post-transcriptional regulators. Various studies have demonstrated that RNA-binding proteins, functioning in ribonucleoprotein… read more here.
Keywords: tob1 tob2; fiber cells; lens fiber; rna processing ... See more keywords
Proteome‐transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.10.011
Abstract: ABSTRACT Epithelial cells and differentiated fiber cells represent distinct compartments in the ocular lens. While previous studies have revealed proteins that are preferentially expressed in epithelial vs. fiber cells, a comprehensive proteomics library comparing the… read more here.
Keywords: mouse lens; epithelium fibers; analysis; lens epithelium ... See more keywords
Proteomic analysis of the glutathione‐deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.09.019
Abstract: Purpose To determine global protein expression changes in the lens of the GSH‐deficient LEGSKO mouse model of age‐related cataract for comparison with recently published gene expression data obtained by RNA‐Seq transcriptome analysis. Methods Lenses were… read more here.
Keywords: response; deficient; analysis; legsko ... See more keywords
Nucleolar ribosomal RNA synthesis continues in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency
Sign Up to like & getrecommendations! Published in 2025 at "RNA Biology"
DOI: 10.1080/15476286.2025.2483118
Abstract: ABSTRACT Cellular differentiation requires highly coordinated action of all three transcriptional systems to produce rRNAs, mRNAs and various ‘short’ and ‘long’ non-coding RNAs by RNA Polymerase I, II and III systems, respectively. RNA Polymerase I… read more here.
Keywords: lens fiber; rrna; rna; fiber cells ... See more keywords