Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability
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DOI: 10.1038/s41598-017-05817-9
Abstract: Prostacyclin (PGI2) modulates platelet activation to regulate haemostasis. Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation. It was hypothesised that PGI2 could reverse platelet spreading by… read more here.
Keywords: prostacyclin; fibre formation; pgi2; formation ... See more keywords
Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi
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DOI: 10.1038/s41598-018-21167-6
Abstract: Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytoskeleton reversing platelet… read more here.
Keywords: fibre formation; stress fibre; inhibition; formation ... See more keywords