A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion
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DOI: 10.1021/jacs.4c02262
Abstract: Oligomeric species populated during α-synuclein aggregation are considered key drivers of neurodegeneration in Parkinson’s disease. However, the development of oligomer-targeting therapeutics is constrained by our limited knowledge of their structure and the molecular determinants driving… read more here.
Keywords: terminal motif; conversion; oligomer fibril; fibril conversion ... See more keywords