Structural optimization of inhibitors of α-synuclein fibril growth: affinity to the fibril end as a crucial factor.
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DOI: 10.1016/j.jmb.2019.11.019
Abstract: BACKGROUND Misfolding of the neuronal protein α-synuclein into amyloid fibrils is a pathological hallmark of Parkinson's disease, a neurodegenerative disorder that has no cure. Inhibition of the fibril growth is considered a promising therapeutic approach.… read more here.
Keywords: synuclein fibril; affinity; fibril growth; affinity fibril ... See more keywords