Hyperstable and Fibril-Forming Collagen-Mimetic Peptides in Shortest Triple Helices: Empowering the Capping by π-systems.
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c01455
Abstract: Developing collagen-mimetic peptides (CMPs) with short triple helices and fibril-forming ability remains challenging. Herein, we stabilized short CMPs (3-6 GPO repeats) by attaching extended aromatic π-system─fluorenyl groups at the N-terminus and tyrosine at the C-terminus.… read more here.
Keywords: mimetic peptides; fibril forming; collagen mimetic; triple helices ... See more keywords
Designed Fibril-Forming Mini-Collagens Engineered to Exhibit up to Two Orders of Magnitude Differences in Rates of Matrix Metalloproteinase I Susceptibility
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DOI: 10.1021/acs.biomac.5c00026
Abstract: The susceptibility to matrix metalloproteinases (MMPs) directly affects the functions and applications of collagen biomaterials. In this work, we demonstrated that this property can be manipulated in collagen-mimetic biomaterials created using designed peptides. We developed… read more here.
Keywords: two orders; susceptibility; fibril forming; orders magnitude ... See more keywords
Distribution and Structure Analysis of Fibril-Forming Peptides Focusing on Concentration Dependency
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DOI: 10.1021/acsomega.1c04960
Abstract: We focus on the concentration dependency of fibril-forming peptides, which have the potential of aggregation by themselves. In this study, we performed replica-exchange molecular dynamics simulations of Lys-Phe-Phe-Glu (KFFE) fragments, which are known to form… read more here.
Keywords: structure; fibril forming; concentration; forming peptides ... See more keywords
Physicochemical characteristics and fibril-forming properties of collagen from paddlefish (Polyodon spathula) and globefish (Fugu flavidus) skin byproducts
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DOI: 10.1590/1678-457x.15416
Abstract: Acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) from the skin byproducts of paddlefish (ASC-P and PSC-P) and globefish (ASC-G and PSC-G) were purified and characterized. The imino acid contents of ASC-P, PSC-P, ASC-G and PSC-G… read more here.
Keywords: asc psc; fibril forming; skin byproducts; microscopy ... See more keywords
The Amyloid Fibril-Forming β-Sheet Regions of Amyloid β and α-Synuclein Preferentially Interact with the Molecular Chaperone 14-3-3ζ
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26206120
Abstract: 14-3-3 proteins are abundant, intramolecular proteins that play a pivotal role in cellular signal transduction by interacting with phosphorylated ligands. In addition, they are molecular chaperones that prevent protein unfolding and aggregation under cellular stress… read more here.
Keywords: fibril forming; amyloid synuclein; spectroscopy; amyloid fibril ... See more keywords