Structural optimization of inhibitors of α-synuclein fibril growth: affinity to the fibril end as a crucial factor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.11.019
Abstract: BACKGROUND Misfolding of the neuronal protein α-synuclein into amyloid fibrils is a pathological hallmark of Parkinson's disease, a neurodegenerative disorder that has no cure. Inhibition of the fibril growth is considered a promising therapeutic approach.… read more here.
Keywords: synuclein fibril; affinity; fibril growth; affinity fibril ... See more keywords
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00327
Abstract: Recent high-resolution structures of alpha-synuclein (aSyn) fibrils offer promise for rational approaches to drug discovery for Parkinson's disease and Lewy body dementia. Harnessing the first such structures, we previously used molecular dynamics and free energy… read more here.
Keywords: fibril growth; alpha synuclein; threonine cavities; threonine ... See more keywords
Identification of small molecule dimethyoxyphenyl piperazine inhibitors of alpha-synuclein fibril growth
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-17658-y
Abstract: Alpha-synuclein (asyn) fibril accumulation is the defining feature of Parkinson disease and is a target for disease-modifying treatments. One therapeutic strategy to reduce fibril accumulation is inhibition of asyn fibril growth. We developed a sensitive… read more here.
Keywords: inhibition; small molecule; growth; alpha synuclein ... See more keywords
Fibril Growth Behavior of Amyloid β on Polymer-Based Planar Membranes: Implications for the Entanglement and Hydration of Polymers
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11104408
Abstract: The design of biosensors and artificial organs using biocompatible materials with a low affinity for amyloid β peptide (Aβ) would contribute to the inhibition of fibril growth causing Alzheimer’s disease. We systematically studied the amyloidogenicity… read more here.
Keywords: planar membranes; fibril growth; polymer; polymer based ... See more keywords