Mechanism of rutin mediated inhibition of insulin amyloid formation and protection of Neuro-2a cells from fibril-induced apoptosis
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DOI: 10.1007/s11033-020-05393-8
Abstract: Many metabolic and neurodegenerative diseases are associated with protein misfolding and aggregation. Insulin a key hormone, under certain conditions aggregates and forms pathological amyloid fibrils. Several polyphenols have been studied extensively to elucidate their inhibitory… read more here.
Keywords: insulin; fibril induced; insulin amyloid; rutin ... See more keywords
α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
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DOI: 10.1186/s40478-018-0537-x
Abstract: Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the… read more here.
Keywords: hippocampal neurons; synuclein fibril; fibril induced; syn ... See more keywords
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells
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DOI: 10.26508/lsa.201800280
Abstract: This study provides evidence that exogenous proteinaceous seeds can induce protein aggregates that sequester stress granule components independent of stress granule assembly. Prions of lower eukaryotes are self-templating protein aggregates that replicate by converting homotypic… read more here.
Keywords: protein; stress granule; fibril induced; prion ... See more keywords