Elucidating Important Sites and the Mechanism for Amyloid Fibril Formation by Coarse-Grained Molecular Dynamics.
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DOI: 10.1021/acschemneuro.6b00331
Abstract: Fibrils formed by the β-amyloid (Aβ) peptide play a central role in the development of Alzheimer's disease. In this study, the principles governing their growth and stability are investigated by analyzing canonical and replica-exchange molecular… read more here.
Keywords: molecular dynamics; coarse grained; fibril; monomer ... See more keywords