Inhibition of Aβ1-42 fibrillation by chaperonins: human Hsp60 is a stronger inhibitor than its bacterial homologue GroEL.
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DOI: 10.1021/acschemneuro.9b00183
Abstract: Alzheimer's disease is a chronic neurodegenerative disease characterized by the accumulation of pathological aggregates of amyloid beta peptide. Many efforts have been focused on understanding peptide aggregation pathways and on identification of molecules able to… read more here.
Keywords: aggregation; human hsp60; groel; fibrillation chaperonins ... See more keywords