Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
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DOI: 10.1039/d2ra00614f
Abstract: A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of… read more here.
Keywords: contrast agent; amyloid fibrillation; fibrillation process; mri contrast ... See more keywords